JOHN E KELLY
Medical Practice in Rockville, MD

6927068, Aug 9, 2005

Jan 30, 2002

10/060605

Lloyd G. Simonson - Spring Grove IL, US
John R. Kelly - Rockville MD, US

The United States of America as represented by the Secretary of the Navy - Washington DC

G01N033/53

436518, 436517, 436514, 436528, 436530, 436541, 436810, 422 56, 422 57, 422 58, 422 59, 422 60, 435 71, 435 793, 435 794, 435970, 43525231

An assay method and kit for detecting the presence of a predesignated, target IgG antibody in a sample selected from one or more patient bodily fluids. The method comprises the following steps: (a) contacting the sample of one or more patient bodily fluids with a membrane-bound recombinant protective antigen to bind to the target IgG antibody in the sample; (b) previously, simultaneously or subsequently to step (a), binding the protective antigen (PA) with a conjugated label producing a detectable signal; and (c) detecting the signal whereby the presence of the target IgG antibody is determined in the sample by the intensity of the signal. The method can further comprise the step of evaluating immunization status of the patient from whom the sample came by comparing the signal or lack thereof with immunizations previously received by the patient. In a preferred embodiment, the recombinant protective antigen (PA) specifically binds to anthrax protective antigen-specific IgG antibodies. Preferably, the immunoassay of the present invention comprises a lateral-flow assay comprising a membrane, a conjugated label pad, and a recombinant protective antigen (PA) bound to the membrane.

5676745, Oct 14, 1997

Jun 7, 1995

8/487557

John Robert Kelly - Derwood MD
Joseph M. Antonucci - Kensington MD

The United States of America, as represented by the Secretary of Commerce - Washington DC

C09K 300

106 35

Composites in the form of a three-dimensional framework or skeleton of ceic particles are formed by a low cost, low temperature sintering process which decomposes a pre-ceramic inorganic or organic precursor. Upon heating, preferably in air, the precursor decomposes to form a ceramic phase in the form of necks between the individual ceramic particles. The properties of the resulting porous ceramic bodies can be modified, such as toughened by impregnation with monomers, oligomers or polymers which are polymerized or cured in situ. Such composites find use as cosmetic products or protheses for humans and animals, such as dental restoratives and bone implants. Methods of fabrication are disclosed which include the use of a pre-ceramic polymer as a binder for the ceramic particles which forms the necks of material between the individual ceramic particles upon firing.