JOHN E HEVERAN
Medical Practice in Fairfield, NJ

4101549, Jul 18, 1978

May 26, 1976

5/690123

Antonino Focella - Clifton NJ
John Edward Heveran - Fairfield NJ
Sidney Teitel - Clifton NJ
Manfred Weigele - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D23962

544301

Aminoaryl esters and amino-lower alkyl amides of carboxy substituted barbiturates are linked via an amide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of barbiturates in body fluids. The large increase in the abuse of therapeutic agents, particularly the barbiturates, by the general population as well as military personnel, has brought with it a substantial need to improve analytical techniques for the determination of such agents in biological fluids. In many instances, medical treatment centers are faced with the immediate need for determining the identity of a barbiturate taken by a patient who is unable, being in a comatose condition, or unwilling to supply such information to the treating physician. Early procedures involved the identification of barbiturates by extraction and thin-layer, gas chromatographic and spectrophotometric methods. These techniques have the disadvantages of being relatively time-consuming, laborious and lacking great sensitivity.

4438207, Mar 20, 1984

Apr 13, 1981

6/254022

Kenneth E. Fahrenholtz - Bloomfield NJ
John E. Heveran - Fairfield NJ

Hoffmann-La Roche Inc. - Nutley NJ

G01N 3354, C07G 700, C07D31178

436543

An improved immunoassay for detecting cannabinoids is described. This immunoassay is characterized by utilizing, as reagents, antibody,. sup. 125 I-radiolabeled antigen, an unlabeled antigen and an anion exchange resin for separation of labeled and unlabeled antigen. The iodinated tetrahydrocannabinol moiety is stabilized by the addition of small quantities of antioxidants such as butylated hydroxy toluene.

4196185, Apr 1, 1980

Jun 5, 1978

5/912272

Antonino Focella - Clifton NJ
John E. Heveran - Fairfield NJ

Hoffmann-La Roche Inc. - Nutley NJ

A61K 4300, G01N 3316

424 1

An improved immunoassay for detecting the drug of abuse phencyclidine is described. This immunoassay is characterized in utilizing as reagents (i) an antibody elicited with a novel immunogen comprising 4-[(1-piperidinyl)cyclohexyl] benzoic acid covalently bonded to an immunogenic carrier material through the carboxyl group and (ii) a novel radiolabeled derivative of phencyclidine, namely. sup. 125 I N-(4-hydroxy-2-phenylethyl)-4-[1-(1-piperidinyl)cyclohexyl] benzamide.

4340736, Jul 20, 1982

Dec 5, 1979

6/100328

Antonino Focella - Clifton NJ
John E. Heveran - Fairfield NJ
Sidney Teitel - Clifton NJ
Manfred Weigele - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

C07D23962

544301

Aminoaryl esters and amino-lower alkyl amides of carboxy substituted barbiturates are linked via an amide linkage to carboxylated latex polymers to form reagents which are useful in a sensitive diagnostic test to detect the presence of barbiturates in body fluids.

4104367, Aug 1, 1978

Oct 13, 1976

5/731620

Magdalena Usategui Gomez - Wayne NJ
Harvey Gurien - Irvington NJ
John Edward Heveran - Fairfield NJ
Manfred Weigele - North Caldwell NJ

Hoffmann-La Roche Inc. - Nutley NJ

G01N 3316, A61K 4300

424 1

An improved immunoassay for methadone is disclosed. The subject radioimmunoassay utilizes a novel antigen, antibody and novel labelled methadone derivatives.