Inventors:
Liming Shao - Lincoln MA, US
Fengjiang Wang - Northborough MA, US
Scott Malcolm - Southborough MA, US
Michael Hewitt - Somerville MA, US
Larry Bush - Worcester MA, US
Jianguo Ma - Natick MA, US
Mark Varney - Laguna Niguel CA, US
Una Campbell - Marlborough MA, US
Sharon Engel - Hudson MA, US
Larry Hardy - Sturbridge MA, US
Patrick Koch - Marlborough MA, US
John Campbell - Waban MA, US
Assignee:
SEPRACOR INC. - Marlborough MA
International Classification:
A61K 31/55, A61K 31/445, A61K 31/40, A61K 31/397, A61K 31/396, C07D 211/06, C07D 203/04, C07D 207/04
US Classification:
514183000, 514212010, 514319000, 514408000, 548577000, 546205000, 540484000, 514210010, 548950000, 548954000
Abstract:
The invention relates to novel cyclohexylamine derivatives and their use in the treatment and/or prevention of central nervous system (CNS) disorders, such as depression, anxiety, schizophrenia and sleep disorder as well as methods for their synthesis. The invention also relates to pharmaceutical compositions containing the compounds of the invention, as well as methods of inhibiting reuptake of endogenous monoamines, such as dopamine, serotonin and norepinephrine from the synaptic cleft and methods of modulating one or more monoamine transporter.