JOHN DREW PRUGH
Pharmacy in Chalfont, PA
License number
Pennsylvania RP026888L
Category
Pharmacy
Type
Pharmacist
Address
Address
Chalfont, PA 18914
Personal information
See more information about JOHN DREW PRUGH at radaris.comName
Address
Phone
127 Prughs Ln, Rural Valley, PA 16249
16 Far View Rd, Chalfont, PA 18914
2811 Oregon St, Easton, PA 18045
16 Far View Rd, Chalfont, PA 18914
20 Magnolia Cir, Shrewsbury, PA 17361
Professional information
3-O-Benzyl-2,4,6-Tridooxy-6-Iodo-Alpha-D-Erythro-Hexopyranide Useful For Preparing Inhibitors Of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase
US Patent:
4683314, Jul 28, 1987
Filed:
Apr 28, 1986
Appl. No.:
6/858899
Inventors:
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D30906
US Classification:
549417
Abstract:
Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.
Process For Preparing Inhibitors Of 3-Hydroxy-3-Methylglutaryl Coenzyme A Reductase Via A Chiral Synthon
US Patent:
4540796, Sep 10, 1985
Filed:
Jan 6, 1984
Appl. No.:
6/568977
Inventors:
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D30930
US Classification:
549292
Abstract:
Totally synthetic analogs of the known inhibitors of 3-hydroxy-3-methylglutaryl coenzyme A reductase, compactin and mevinolin, are prepared from a chiral synthon derived from D-glucose which has the same chirality as the natural products.
Piperidylidene Derivatives Of Cyano-5H-Dibenzo[A,D]Cycloheptene
US Patent:
3988342, Oct 26, 1976
Filed:
Jun 5, 1974
Appl. No.:
5/476630
Inventors:
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D21178
US Classification:
26029362
Abstract:
Disclosed are 1-, 2-, or 3-cyano-N-alkyl-5H-dibenzo[a,d]-cyclohepten-5-ylidene piperidine compounds having pharmaceutical utility as tranquilizers; also disclosed are processes for the preparation of such compounds; pharmaceutical compositions comprising such compounds; and methods of treatment comprising administering such compounds and compositions when a tranquilizing effect is indicated.
Appetite Stimulating And Antihistaminic 3-Hydroxymethylcyproheptadine And Analogs
US Patent:
4212871, Jul 15, 1980
Filed:
Mar 2, 1979
Appl. No.:
6/016771
Inventors:
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31445, C07D21170
US Classification:
424267
Abstract:
3-Hydroxymethyl derivatives of cyproheptadine and related compounds are appetite stimulants and antihistaminic agents.
Suppression Of Gastric Acid Secretion Using Pyrimidylcarbamates
US Patent:
4415575, Nov 15, 1983
Filed:
Feb 5, 1982
Appl. No.:
6/345957
Inventors:
William A. Bolhofer - Frederick PA
John D. Prugh - Chalfont PA
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31505
US Classification:
424251
Abstract:
Heterocyclic carbamates are disclosed which have potent gastric secretion inhibitory properties. The heterocyclic substituent is a pyridyl group or a 6-membered heterocycle with two nitrogen heteroatoms, which may be optionally substituted. Further substituents on the carbamate nitrogen and oxygen atoms are also disclosed. The compounds have profound effects on the inhibition of gastric secretions in the gastro-intestinal tract, and compositions for such uses are also disclosed.
Substituted Thieno[3,2-B]Thiophene-2-Sulfonamides As Topically Active Carbonic Anhydrase Inhibitors
US Patent:
4876271, Oct 24, 1989
Filed:
Dec 20, 1988
Appl. No.:
7/286822
Inventors:
George D. Hartman - Lansdale PA
John D. Prugh - Chalfont PA
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D49504, A61K 3138
US Classification:
514443
Abstract:
Novel substituted thieno[3,2-b]thiophene-2-sulfonamides are prepared by novel synthetic processes. These compounds are useful for the treatment of elevated intraocular pressure in compositions including ophthalmic drops and inserts.
4-(10,11-Dihydro-Cis And Trans-10,11-Dihydroxy-5H-Dibenzo[A,D]Cyclohepten-5-Ylidene)-Piperidines
US Patent:
4089864, May 16, 1978
Filed:
Mar 25, 1974
Appl. No.:
5/454195
Inventors:
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D21122
US Classification:
26029362
Abstract:
10,11-dihydroxy derivatives of 10,11-dihydro cyproheptadine useful as appetite enhancers and as antihistaminic agents are prepared from a process including bromination and alkaline hydrolysis of the resulting 10,11-dibromo compounds.
Novel Hmg-Coa Reductase Inhibitors
US Patent:
4946864, Aug 7, 1990
Filed:
Feb 1, 1988
Appl. No.:
7/150586
Inventors:
John Prugh - Chalfont PA
Albert A. Deana - Lansdale PA
Clarence S. Rooney - Worcester PA
Albert A. Deana - Lansdale PA
Clarence S. Rooney - Worcester PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31335, C07D30930
US Classification:
514460
Abstract:
Novel HMG-CoA reductase inhibitors of formulae (I) and (II) are disclosed. ##STR1##.
Fibrinogen Receptor Antagonists
US Patent:
5559127, Sep 24, 1996
Filed:
May 31, 1995
Appl. No.:
8/416770
Inventors:
George D. Hartman - Lansdale PA
John D. Prugh - Chalfont PA
Melissa S. Egbertson - Ambler PA
Mark E. Duggan - Schwenksville PA
William Hoffman - Lansdale PA
Ben Askew - Lansdale PA
John D. Prugh - Chalfont PA
Melissa S. Egbertson - Ambler PA
Mark E. Duggan - Schwenksville PA
William Hoffman - Lansdale PA
Ben Askew - Lansdale PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
A61K 31445, C07D40106, C07D40506, C07D40906
US Classification:
514322
Abstract:
Fibrinogen receptor antagonists of the formula: ##STR1## wherein A,B,D,E,Y are as defined in the specification, are disclosed for use in inhibiting the binding of fibrinogen to blood platelets and for inhibiting the aggregation of blood platelets.
Synthetic Analogs Of Mevinolin
US Patent:
4654363, Mar 31, 1987
Filed:
Nov 4, 1985
Appl. No.:
6/794890
Inventors:
John D. Prugh - Chalfont PA
Assignee:
Merck & Co., Inc. - Rahway NJ
International Classification:
C07D30930, A61K 31365
US Classification:
514460
Abstract:
Certain 6-(substituted-naphthyl)hydrocarbyl-4-hydroxytetrahydropyran-2-ones are unexpectedly potent in the treatment of familial hypercholesterolemia, hyperlipemia and atherosclerosis by virtue of their ability to inhibit the enzyme, 3-hydroxy-3-methylglutaryl-coenzyme A reductase (HMG-CoA reductase).