JOHN DEGREE HENION
Pilots at Iradell Rd, Trumansburg, NY

4935624, Jun 19, 1990

Jun 3, 1988

7/202768

John D. Henion - Trumansburg NY
Edgar D. Lee - Ithaca NY
Thomas R. Covey - Ithaca NY

Cornell Research Foundation, Inc. - Ithaca NY

H01J 4910

250288

A Thermal-Assisted Electrospray Interface (TAESI) used in series between a liquid chromatograph and a mass analyzer gives increased sensitivity for detection of components in a liquid stream at high flow rates up to 2 milliliters per minute. Liquid exiting the liquid chromatograph is sprayed through a stainless steel capillary tube while being heated externally and under an applied voltage of about 3 KV. The combination of thermal energy and electric field potential disperses the liquid into a fine mist which is then directed at atmospheric pressure into the ionization chamber of a mass spectrometer. Such a system, optionally may additionally contain a high velocity gas flow neubulization means. The TAESI interface may be used without the electric field; however at flow rates of from 500 to 1000. mu. L/min the use of both electric field and thermal energy increases the sensitivity by two orders of magnitude over the interface used without the electric field.

5352892, Oct 4, 1994

Jan 26, 1993

8/009063

Alex Mordehai - Ithaca NY
Gerard Hopfgartner - Ithaca NY
John D. Henion - Trumansburg NY

Cornell Research Foundation, Inc. - Ithaca NY

B01D 5944, H01J 4900

250288

A novel atmospheric pressure ionization device for the transport of charged particle produced by at atmospheric pressure to a mass analyzer includes a liquid shield between the particle source and the sample inlet into the mass analyzer. The liquid shield may be in the form of a disk with a central aperture and acts as a spray splitter and aerofocusing device which increases the flow rate of a liquid sample into the analyzer. The mass analyzer is located in a high vacuum region and an intermediate low vacuum region is provided between the sample inlet and the analyzer. An ion optical system includes electrostatic lens assemblies in said vacuum regions for transporting charged particles from the inlet to the analyzer.

5268572, Dec 7, 1993

Sep 23, 1992

7/948394

Alex Mordehai - Ithaca NY
John D. Henion - Trumansburg NY

Cornell Research Foundation, Inc. - Ithaca NY

H01J 4924, H01J 4942

250289

An ion trap mass spectrometer includes an ion trap region separated from an electron multiplier region by a baffle, and separate turbomolecular pumps for pumping each region to a different pressure level. The ion trap region can therefore be pumped to a higher pressure level than ca be used for the electron multiplier region, and the result and increase in pressure of damping gas in the ion trap region increases the sensitivity of the device.

2010007, Apr 1, 2010

Sep 23, 2009

12/565320

Thomas Corso - Groton NY, US
John D. Henion - Trumansburg NY, US

ADVION BIOSCIENCES, INC. - Ithaca NY

H01J 49/04

250288, 250292

Atmospheric pressure ionization (API) interface structures such as API interface structures for mass spectrometers and related components, systems and methods are described herein.

4861988, Aug 29, 1989

Sep 30, 1987

7/103056

John D. Henion - Trumansburg NY
Thomas R. Covey - Houston TX
Andries P. Bruins - Leek, NL

Cornell Research Foundation, Inc. - Ithaca NY

B01D 5944

290288

A device for interfacing between a microbore liquid chromatograph and a mass analyser. In such a device, liquid from the liquid chromatograph is sprayed through a stainless steel capillary tube into the atmospheric pressure ionization chamber of a mass spectrometer. A voltage of e. g. , plus or minus 3 KV is applied to the stainless steel tube, and a nebulizing gas, e. g. nitrogen, is directed at high velocity past the tube tip through another tube encircling the stainless steel tube. The combination of the nebulizing gas and the electric potential disperses the liquid at room temperature into a fine mist providing an increased and more stable ion signal without thermal decomposition of the compounds being analysed.

8546752, Oct 1, 2013

Dec 3, 2010

12/960037

John D. Henion - Trumansburg NY, US
Thomas Kurz - Ithaca NY, US

Advion Inc. - Ithaca NY

H01J 49/26

250288, 250282

Methods and systems for extraction of analytes from samples for analysis using mass spectrometers are described herein.

8445842, May 21, 2013

Jul 30, 2012

13/561358

Daniel Eikel - Trumansburg NY, US
John D. Henion - Trumansburg NY, US
Christopher Alpha - Ithaca NY, US
Jason Scott Vega - Ithaca NY, US

Advion, Inc. - Ithaca NY

G01N 1/00, G01N 1/28, H01J 49/26

250281, 250288, 250428, 7386491, 436174, 422527, 422561

A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.

8294087, Oct 23, 2012

May 4, 2011

13/100383

Daniel Eikel - Lansing NY, US
John D. Henion - Trumansburg NY, US
Christopher Alpha - Ithaca NY, US
Jason Scott Vega - Ithaca NY, US

Advion, Inc. - Ithaca NY

G01N 1/00, G01N 1/28, H01J 49/26

250282, 250281, 250288, 250428, 7386491, 436174

A mechanical holder that provides for a confined sampling region for extraction and removal of chemical substances contained in a dried blood spot or other spot of sample is described herein.