DR. JOHN DANIEL DOBAK, M.D.
Osteopathic Medicine at Chelsea St, La Jolla, CA

2005022, Oct 13, 2005

Jun 13, 2005

11/151488

Steven Yon - San Diego CA, US
John Dobak - La Jolla CA, US
Hans Kramer - Temecula CA, US
Rebecca Inderbitzen - San Diego CA, US

A61B018/02

606021000, 606023000, 606024000, 607104000, 607113000

An enhanced method and device are provided to treat atrial fibrillation or inhibit or reduce restenosis following angioplasty or stent placement. A balloon-tipped catheter is disposed in the area treated or opened through balloon angioplasty immediately following angioplasty. The balloon, which can have a dual balloon structure, may be delivered through a guiding catheter and over a guidewire already in place. A fluid such as a perfluorocarbon flows into the balloon to freeze the tissue adjacent the balloon, this cooling being associated with reduction of restenosis. A similar catheter may be used to reduce atrial fibrillation by inserting and inflating the balloon such that an exterior surface of the balloon contacts at least a partial circumference of the portion of the pulmonary vein adjacent the left atrium. In another embodiment, blood perfusion is performed simultaneously. In another embodiment, tissue contacted by the cryoablation catheter, undesired to be ablated, is protected against damage by a separate heating step.

2001002, Oct 11, 2001

Feb 27, 2001

09/797028

John Dobak - La Jolla CA, US
Juan Lasheras - La Jolla CA, US
Randell Werneth - San Diego CA, US

A61F007/00, A61F007/12

607/105000, 607/113000

A guidable catheter for heating or cooling a surrounding fluid in a feeding vessel in a vasculature of a patient. The catheter includes a heat transfer element, the heat transfer element having a plurality of exterior surface irregularities shaped and arranged to create turbulence in a surrounding fluid. The surface irregularities have a depth at least equal to the boundary layer thickness of flow of the surrounding fluid in the feeding vessel. The catheter assembly also includes a supply catheter having a portion disposed within the heat transfer element to deliver a working fluid to an interior of the heat transfer element. The catheter assembly further includes a return catheter to return a working fluid from the interior of the heat transfer element. A guidewire tube is provided adjacent one of the supply catheter or the return catheter and runs substantially parallel to the axis of the guidable catheter to receive a guidewire disposed within the guidewire tube. The guidable catheter may further have a temperature-monitoring device disposed at the distal tip of the guidewire. The temperature-monitoring device may be a thermocouple or a thermistor. Feedback may further be provided to control the temperature of a source of working fluid. A method is also provided for selectively controlling the temperature of a selected volume of blood in a patient. The method includes introducing a guidewire into a blood vessel feeding a selected volume of blood in a patient and introducing a catheter assembly into the blood vessel feeding a selected volume of blood in a patient by inserting the guidewire into a guidewire tube in the catheter assembly. A working fluid is delivered from a source of working fluid through a supply catheter in the catheter assembly and returned through a return catheter in the catheter assembly. Heat is transferred between a heat transfer element forming a distal end of the catheter assembly and the volume of blood in the feeding vessel. The temperature is monitored of the volume of blood in the feeding vessel by measuring the temperature with a temperature-monitoring device disposed at or near the distal tip of the guidewire.

2002004, Apr 25, 2002

Dec 3, 2001

10/005056

Randell Werneth - San Diego CA, US
Kevin Gilmartin - Encinitas CA, US
Steven Yon - San Diego CA, US
Juan Lasheras - La Jolla CA, US
John Dobak - La Jolla CA, US

Innercool Therapies, Inc. - San Diego CA

A61F007/00, A61F007/12

607/105000, 607/113000

The invention provides a device for heating or cooling a surrounding fluid in a feeding vessel and a method of manufacturing the same. The device includes a catheter assembly capable of insertion to a selected blood vessel in the vascular system of a patient. The assembly includes an elongated catheter body, a heat transfer element located at a distal portion of the catheter body and including an interior, an elongated supply lumen adapted to deliver a working fluid to the interior of the heat transfer element and having a hydraulic diameter, an elongated return lumen adapted to return a working fluid from the interior of the heat transfer element and having a hydraulic diameter, and wherein the ratio of the hydraulic diameter of the return lumen to the hydraulic diameter of the supply lumen is substantially equal to 0.75. The method of manufacturing the catheter assembly involves extruding an elongated catheter body; locating a heat transfer element including an interior at a distal portion of the catheter body; extruding an integrated elongated bi-lumen member including a first lumen adapted to receive a guide wire and a second lumen having a hydraulic diameter, the second lumen comprising either a supply lumen to deliver a working fluid to an interior of the heat transfer element or a return lumen to return a working fluid from the interior of the heat transfer element; and providing the integrated bi-lumen member substantially within the elongated catheter body so that a third lumen having a hydraulic diameter is formed, the third lumen comprising either a supply lumen to deliver a working fluid to an interior of the heat transfer element or a return lumen to return a working fluid from the interior of the heat transfer element and the ratio of the second lumen hydraulic diameter to the third lumen hydraulic diameter is substantially equal to 0.75.

7702386, Apr 20, 2010

Jan 24, 2007

11/657877

John D. Dobak - La Jolla CA, US
Hans Neisz - Coon Rapids MN, US

Leptos Biomedical, Inc. - Fridley MN

A61N 1/08

607 2

The disclosure provides a description of a tissue modulation device, for treating at least one of obesity, metabolic syndrome, and Type 2 diabetes in a patient. In some embodiments, the device includes a storage module having computer-readable instructions for delivering an electrical stimulation pattern to a splanchnic nerve of the patient. The stimulation pattern includes at least one on-time. The on-time includes at least one of a suprathreshold period and a subthreshold period. The splanchnic nerve is selected from the group consisting of the greater splanchnic nerve, the lesser splanchnic nerve, and the least splanchnic nerve. The pattern is effective to ameliorate at least one attendant condition of obesity, metabolic syndrome, and Type 2 diabetes in the patient. The attendant condition includes dyslipidemia, hypertension, hyperinsulinemia, hyperglycemia, and/or insulin resistance.

2003006, Mar 27, 2003

Aug 9, 2002

10/216405

John Dobak - La Jolla CA, US

A61F007/00

607/104000, 607/105000

Embodiments of the invention provide a system for temperature control of the human body. The system includes an indwelling catheter with a tip-mounted heat transfer element. The catheter is fluidically coupled to a console that provides a heated or cooled heat transfer working fluid to exchange heat with the heat transfer element, thereby heating or cooling blood. The heated or cooled blood then heats or cools the patient's body or a selected portion thereof. In particular, strategies for providing cooling while reducing shivering are disclosed, including administration of various drugs and drug combinations.

2011022, Sep 15, 2011

Jan 14, 2011

13/007518

John Daniel Dobak - La Jolla CA, US
Chris Kemmerer - San Diego CA, US
Kenneth Walter Locke - Carlsbad CA, US

Lithera, Inc. - San Diego CA

A61K 31/56, A61K 31/138, A61P 3/04, A61P 9/00, A61P 3/10

514171, 514180, 514651

Provided herein are lyophilized cake forms of fluticasone, salmeterol, or a pharmaceutically acceptable salt or a combination thereof which provides room temperature stability for an extended period of time. Upon reconstitution with an acceptable solvent (e.g., a carrier or diluent), the reconstituted pharmaceutical or cosmetic formulation provides a sterile, non-suspension form suitable for parenteral injectable administration, including subcutaneous injection.

2001000, May 31, 2001

Jan 4, 2001

09/754452

John Dobak - La Jolla CA, US

A61F007/00

607/105000, 607/113000

A selective organ cooling device with a separate warming device for preventing secondary cooling which can result from cooling the selected organ. The cooling device applies cooling to the blood flowing in a selected blood vessel, while the body temperature control device warms the whole body either directly, or by warming blood returning to the heart from the selected organ, via a vein.

2004010, Jun 3, 2004

Nov 14, 2003

10/714070

John Dobak - La Jolla CA, US
Juan Lasheras - La Jolla CA, US

Innercool Therapies, Inc.

A61F007/00

607/105000, 607/106000, 607/113000

A catheter system and method are provided which change the temperature of a fluid, such as blood, by heat transfer. Selective cooling or heating of an organ may be performed by changing the temperature of the blood feeding the organ. The catheter system includes an inlet lumen and an outlet lumen structured and arranged to carry a working fluid having a temperature different from the adjacent blood. The outlet lumen is configured to induce turbulence in the adjacent fluid passing adjacent the outlet lumen.

2006027, Dec 7, 2006

Aug 16, 2006

11/504856

John Dobak - La Jolla CA, US
Steven Yon - San Diego CA, US
Michael Magers - Encinitas CA, US

A61F 7/00, A61F 7/12

607105000, 607113000

A device and method for providing body cooling for treating fever. The cooling device applies cooling to blood flowing in a vein or artery, e.g., the vena cavae, that is then distributed throughout the body.

2008022, Sep 11, 2008

May 13, 2008

12/152160

John D. Dobak - La Jolla CA, US

Innercool Therapies, Inc. - San Diego CA

A61B 18/02

607106

The use of an intravascular cooling element to induce hypothermia in connection with a medical procedure. According to a first aspect of the present, invention, a coronary bypass procedure is conducted in which a patient's blood is oxygenated with the patient's lungs and in which blood is circulated using the patient's heart or using an intracorporeal pump. The procedure preferably comprises: (a) positioning a heat transfer element in a blood vessel of a patient; (b) cooling the body of the patient to less than 35° C., more preferably 32±2° C., using the heat transfer element; and (c) forming a fluid communicating graft between an arterial blood supply and the coronary artery. The body of the patient is preferably heated to about 37° C. using the heat transfer element subsequent to the step of forming the fluid communicating graft. According to a further aspect of the invention, a hypothermic medical procedure is provided while a patient is in a conscious or semiconscious state, comprising (a) administering a beta-blocking drug to the patient; (b) delivering a heat transfer element to a blood vessel of the patient; and (c) cooling a region of the patient or the body of the patient to less than 35° C. using the heat transfer element.