JOHN D ROBACK
Medical Practice at Lewis Dr, Smyrna, GA
License number
Florida 112273
Issued Date
Mar 1, 2012
Effective Date
Mar 1, 2012
Expiration Date
Jan 31, 2018
Category
Health Care
Type
Medical Doctor
Address
Address
4951 Lewis Dr SE, Smyrna, GA 30082
Phone
(404) 788-8565
Professional information
Methods For The Treatment Of Graft-Versus-Host Disease
US Patent:
8486408, Jul 16, 2013
Filed:
Oct 2, 2009
Appl. No.:
13/121016
Inventors:
Mohammad S. Hossain - Norcross GA, US
Andrew T. Gewitz - Smyrna GA, US
John D. Roback - Smyrna GA, US
Edmund K. Waller - Atlanta GA, US
Andrew T. Gewitz - Smyrna GA, US
John D. Roback - Smyrna GA, US
Edmund K. Waller - Atlanta GA, US
Assignee:
Emory University - Atlanta GA
International Classification:
A61K 35/28, A61K 39/085
US Classification:
4241721, 4242341, 4242581
Abstract:
Methods are disclosed for treating or preventing graft versus host disease in a subject. The methods include selecting a subject in need of treatment for graft versus host disease; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide, or a polynucleotide encoding the flagellin, thereby treating or preventing graft versus host disease in the subject. Methods are also disclosed for reducing susceptibility to an opportunistic infection in a subject who is a bone marrow transplant recipient. The methods include selecting a subject who has had a bone marrow or hematopoietic stem cell transplant; and administering to the subject a therapeutically effective amount of a TLR5 agonist such as a flagellin polypeptide or a polynucleotide encoding the polypeptide, and administering to the subject an effective amount antigen of the opportunistic infection, thereby reducing the susceptibility to the opportunistic infection in the subject.