John Charles Hakala
Pharmacy at Harvard Ave, Denver, CO
License number
Colorado 11722
Issued Date
Aug 11, 1983
Renew Date
Nov 1, 2015
Expiration Date
Oct 31, 2017
Type
Pharmacist
Address
Address
12873 W Harvard Ave, Denver, CO 80228
Personal information
See more information about John Charles Hakala at radaris.comName
Address
Phone
12873 W Harvard Ave, Denver, CO 80228
2135 Stout St, Denver, CO 80205
12873 Harvard Ave, Denver, CO 80228
Denver, CO
Professional information
See more information about John Charles Hakala at trustoria.com
Sustained Release Formulation Of Melatonin
Sustained Release Formulation Of Melatonin
US Patent:
2010012, May 13, 2010
Filed:
Nov 23, 2009
Appl. No.:
12/623961
Inventors:
Michael TERMAN - New York NY, US
John Charles HAKALA - Lakewood CO, US
John Charles HAKALA - Lakewood CO, US
Assignee:
THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK - New York NY
International Classification:
A61K 31/4045, A61P 25/00, A61P 5/00
US Classification:
514419
Abstract:
The present invention relates to low-dose formulations of melatonin, and methods of use thereof, which provide a sustained release of melatonin so as to rapidly increase plasma levels of melatonin, maintain a relatively high level (which mimics the endogenous level of a young subject) for approximately 5-6 hours, and then decrease so as to achieve low levels by early morning (rapid washout), thereby avoiding a “hangover effect”. The sustained release formulations of the invention may be used to treat a variety of sleep-related disorders, including, but not limited to, delayed onset and maintenance forms of insomnia.