Inventors:
Rigel Pharmaceuticals, Inc. - , US
Ankush Argade - Foster City CA, US
Rajinder Singh - Belmont CA, US
Sambaiah Thota - Fremont CA, US
David Carroll - San Francisco CA, US
Kin Tso - San Francisco CA, US
Vanessa Taylor - San Francisco CA, US
John McLaughlin - San Francisco CA, US
Vadim Markovtsov - San Mateo CA, US
Assignee:
Rigel Pharmaceuticals, Inc. - South San Francisco CA
International Classification:
C07D 239/48, C07D 401/12, C07D 471/08, C07D 295/155, C07D 403/12, C07D 417/12, C07D 413/12
US Classification:
5142278, 435375, 5142305, 5142358, 51425214, 514275
Abstract:
The present disclosure provides 2,4-pyrimidinediamine compounds having antiproliferative activity, compositions comprising the compounds and methods of using the compounds to inhibit cellular proliferation and to treat proliferate diseases such as tumorigenic cancers.