JOHN CARL GODFREY
Pilots at Welsh Rd, Huntingdon Valley, PA

6541644, Apr 1, 2003

Aug 7, 2001

09/924387

Robert L. Pollack - Philadelphia PA
John C. Godfrey - Huntingdon Valley PA

AminoPath Labs, LLC - St. Helens OR

C07D20920

548496, 548497, 562443, 562445

Processes for isolating substantially pure natural L--3-indolylalanine (L--3) from a mixture of amino acids, such as a protein hydrolysate. A protein hydrolysate, for example of casein or soy protein, is passed over a polymeric resin attractive to aromatic amino acids but not attractive to aliphatic amino acids. The aromatic amino acids are retained on the resin while the aliphatic amino acids pass over the resin and are collected. The resin is then washed to displace any residual aliphatic acids which may be physically associated with but not bound to the resin. Thereafter, the resin is eluted with a dilute acid to displace L-phenylalanine and L-tyrosine and provide a solution thereof while allowing L--3 to be retained on the resin. The resin is then further eluted with a dilute base to displace L--3 from the resin and provide a solution of L--3. Substantially pure natural L--3 is recoverable from this solution.

7030248, Apr 18, 2006

Feb 14, 2003

10/367667

Robert L. Pollack - Philadelphia PA, US
John C. Godfrey - Huntingdon Valley PA, US
F. Warren Colvin - Eugene OR, US

AminoPath Labs, LLC - Portland OR

C07D 209/20

548497, 548496, 210661

Processes for extracting amino acids from mixtures of amino acids, and compositions and mixtures formed therefrom. Applications include isolating natural L-β-3-indolylalanine (L-β-3) and providing natural or other amino acid mixtures enriched with the extracted L-β-3. The source of amino acids may include a natural source, such as enzymatic or other natural protein hydrolysates containing mixtures of free amino acids. The process includes contacting the mixture of amino acids with a resin or hydrophobic substance that is attractive to aromatic amino acids but not attractive to aliphatic amino acids to separate the aromatic amino acids from the rest of the mixture. This contacting may include agitating the mixture and hydrophobic substance to increase contact therebetween. The L-β-3 may then be separated from the monocylic amino acids by contacting the hydrophobic substance with an acid, and L-β-3 may be removed from the hydrophobic substance by contact with a base.

5945542, Aug 31, 1999

Feb 26, 1998

9/030952

Robert L. Pollack - Philadelphia PA
John C. Godfrey - Huntingdon Valley PA

C07D20920, B01D 1508

548497

A process for isolating substantially pure natural L-. beta. -3-indolylalanine (L-. beta. -3) from a mixture of amino acids, such as a protein hydrolysate, is described. A protein hydrolysate, for example of casein or soy protein, is passed over a polymeric resin attractive to aromatic amino acids but not attractive to aliphatic amino acids. The aromatic amino acids are retained on the resin while the aliphatic amino acids pass over the resin and are collected. The resin is then washed with water to displace any residual aliphatic acids which may be physically associated with but not bound to the resin. Thereafter, the resin is eluted with a dilute acid to displace L-phenylalanine and L-tyrosine and provide a solution thereof while allowing L-. beta. -3 to be retained on the resin. The resin is then further eluted with a dilute base to displace L-. beta.

2006010, May 18, 2006

Jan 11, 2006

11/330572

Robert Pollack - Philadelphia PA, US
John Godfrey - Huntingdon Valley PA, US
Sharon Gaglia - Veneta OR, US

C07C 227/40, C07D 233/61, C07D 209/20

548498000, 562443000, 562444000, 548335500

Embodiments of the present invention provide processes for extracting amino acids from mixtures of amino acids, and compositions and mixtures formed therefrom. Applications include separating and/or isolating non-aromatic amino acids, and/or separating aromatic amino acids into at least one fraction containing phenylalanine and tyrosine and a fraction containing L-β-3-indolylalanine (L-β-3) and providing natural or other amino acid mixtures thereof. The source of amino acids may include a natural source, such as an enzymaticaly hydrolyzed protein or other natural protein hydrolysates containing mixtures of free amino acids. The processes of embodiments of the present invention include contacting the mixture of amino acids with a resin or hydrophobic substance that is attractive to aromatic amino acids but not attractive to aliphatic amino acids to separate the aromatic amino acids from the rest of the mixture.

6316008, Nov 13, 2001

Sep 3, 1998

9/145975

John C. Godfrey - Huntingdon Valley PA

A61K 900, A61K 952, A61K 920, A61K 922, A61K 4700

424400

Compositions for oral use containing at least one zinc compound, at least one amino acid, a source of ascorbic acid which does not appreciably associate with zinc ions, and a base material. The compositions provide for slow release of zinc upon dissolution in the mouth. The amino acid provides the zinc compound(s) with a palatable taste and no aftertaste. The source of ascorbic acid provides Vitamin C without interacting with zinc and forming unpalatable by-products. A method for making such compositions is also described.

5250569, Oct 5, 1993

Apr 22, 1991

7/688318

John C. Godfrey - Huntingdon Valley PA

Godfrey Science & Design, Inc. - Huntingdon PA

A01N 3712, A01N 3744, A61K 31195

514561

Formulations of aluminum compounds with select amino acids such as glycine (aminoacetic acid) in a base material are described. The base material can be a sweetening agent such as a hard or soft candy base, a syrup, chewing gum, dentifrice, or the like. The advantage of such formulations is that the unpalatable and undesirable tastes and aftertastes of unformulated aluminum compound and of aluminum compounds mixed with a base material are markedly reduced and the products may be slowly dissolved in the mouth to achieve nutritional or therapeutic results. Processes for the satisfactory preparation of the formulations are set forth.