JOHN C SOMBERG
Medical Practice in Green Oaks, IL
License number
Pennsylvania MD041839E
Category
Medicine
Type
Medical Physician and Surgeon
Address
Address
2
Green Oaks, IL 60045
Pennsylvania
Pennsylvania
Personal information
See more information about JOHN C SOMBERG at radaris.comName
Address
Phone
210 Saunders Rd, Lake Forest, IL 60045
PO Box 869, Lake Forest, IL 60045
Lake Forest, IL
3471 Green Bay Rd, North Chicago, IL 60064
3333 Green Bay Rd, North Chicago, IL 60064
Professional information
Thrombosis Warning System
US Patent:
2013019, Jul 25, 2013
Filed:
Jul 27, 2012
Appl. No.:
13/560695
Inventors:
John Somberg - Lake Forest IL, US
Assignee:
ACADEMIC PHARMACEUTICALS INCORPORATED - Lake Bluff IL
International Classification:
A61B 5/02
US Classification:
600438, 600481, 600479, 604 66
Abstract:
The present invention relates to a device for detecting the potential formation of a thrombus in a patient on a ventricular assist device. The device uses an energy source and sensor to detect changes in rheology of the patient.
Methadone Chiral Isolate As An Improved Pharmaceutical
US Patent:
2010001, Jan 14, 2010
Filed:
May 18, 2009
Appl. No.:
12/454373
Inventors:
John Charin Somberg - Lake Forest IL, US
Vasant V. Ranade - Libertyville IL, US
Vasant V. Ranade - Libertyville IL, US
International Classification:
A61K 31/135, C07C 221/00
US Classification:
514648, 564319
Abstract:
Methadone is a frequently employed agent for the treatment of drug addiction and the treatment of pain. Methadone prolongs the cardiac action potential, which on the surface electrocardiogram is represented by QT prolongation. This QT prolongation is known to increase the risk for the development of cardiac arrhythmias, especially the form of ventricular tachycardia known as Torsade de Pointes. For this reason, the FDA has inserted a “black box” warning for potential life threatening arrhythmias. The invention described in this application is the surprising finding that the R-isomer of methadone causes less inhibition of the potassium channel, IKr and thus would have less of a chance of causing life threatening arrhythmias. What is claimed is a method of chirally separating methadone with one isomer having less QT prolongation and more analgesic action that would make a superior pharmacologic agent than the racemate R,S methadone.
Formulation Of Aspirin That Is Stable And Showing Minimal Hydrolysis For Parenteral Administration For The Treatment Of Cardiovascular And Other Disease States
US Patent:
8481600, Jul 9, 2013
Filed:
May 26, 2009
Appl. No.:
12/454847
Inventors:
John Charin Somberg - Lake Forest IL, US
Vasant V Ranade - Libertyville IL, US
Vasant V Ranade - Libertyville IL, US
Assignee:
Academic Pharmaceuticals, Inc. - Lake Bluff IL
International Classification:
A01N 31/14, A61K 31/075
US Classification:
514718, 514715
Abstract:
Disclosed herein are ways to solubilize aspirin for parenteral administration containing aspirin and a diluent NNDMA (N,N-Dimethylacetamide) useful in the treatment of acute coronary syndromes as well as other disease states. The solution so constituted is stable at room temperature for prolonged periods without decomposition and avoids significant hydrolysis of the aspirin and thus the loss of the anti-platelet action when stored.
Synthesis And Separation Of Optically Active Isomers Of Erythromycin And Their Biological Actions
US Patent:
2004006, Apr 8, 2004
Filed:
Nov 17, 2003
Appl. No.:
10/432913
Inventors:
John Somberg - Lake Forest IL, US
Vasant Ranade - Lake Forest IL, US
Vasant Ranade - Lake Forest IL, US
International Classification:
C07H017/08, A61K031/7048
US Classification:
514/029000, 536/007100
Abstract:
The present invention provides methods for purifying and using optically active isomers of erythromycin as well as compositions comprising such optically active isomers. Such optically active isomers having desired actions as an antibiotic substantially separable from undesirable effects on GI motility and the cardiac potassium channels such that the cardiac action potential is not prolonged and the QT interval on the surface EKG (electrocardiogram) is not increased, such that the erythromycin can be useful for more effective therapy of systemic infections. Also disclosed are methods for assaying the levels of such isomers present in the biological fluids.
Chiral Separation, Characterization And Biological Action Of Optically Active Isomers Of Digoxin
US Patent:
2010002, Feb 4, 2010
Filed:
Jul 10, 2008
Appl. No.:
12/217888
Inventors:
John Somberg - Lake Forest IL, US
Vasant V. Ranade - Libertyville IL, US
Vasant V. Ranade - Libertyville IL, US
International Classification:
A61K 31/704, C07H 15/24, A61P 9/00
US Classification:
514 26, 536 61
Abstract:
Disclosed herein is the method for separation of enantiomers or isomers of digoxin. These isomers are to be used-in the treatment of heart failure without adverse or unneeded cardiac actions in humans. Additionally what is claimed is an isolate with less or no cardiac contractile effect but with AV node slowing such that the composition would be an effective therapy for the control of the ventricular response in atrial fibrillation. Also disclosed are methods for assaying these isomeric compounds present in biological fluids to enable the separation of pharmacologic actions.
Parenteral Dextrose Formulation Of Clopidogrel
US Patent:
8513278, Aug 20, 2013
Filed:
Nov 26, 2012
Appl. No.:
13/684785
Inventors:
John C Somberg - Lake Forest IL, US
Assignee:
Academic Pharmaceuticals, Inc. - Lake Bluff IL
International Classification:
A61K 31/44
US Classification:
514301
Abstract:
Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and DW, which is useful in the prevention of platelet aggregation in acute coronary syndrome, acute myocardial infarction or to prevent platelet facilitated thrombosis following coronary angioplasty and/or coronary stenting.
Parenteral Solutions Containing Metolazone
US Patent:
2012007, Mar 29, 2012
Filed:
Mar 30, 2011
Appl. No.:
13/076297
Inventors:
John C. Somberg - Lake Forest IL, US
Vasant V. Ranade - Lake Bluff IL, US
Vasant V. Ranade - Lake Bluff IL, US
Assignee:
ACADEMIC PHARMACEUTICALS INCORPORATED - Lake Bluff IL
International Classification:
A61K 31/517, A61P 7/10, A61P 9/12
US Classification:
5142663
Abstract:
Disclosed herein are parenteral solutions containing 7-halo-1,2,3,4-tetrahydro-3-aryl-6-quinazoline sulfonamide in N,N-dimethylactamide, polyethylene glycol and DW useful in the treatment of hypertension, heart failure and renal disease leading to edematous states. Also disclosed are methods for preparing such solutions.
Parenteral Formulation Of Clopidogrel
US Patent:
8563574, Oct 22, 2013
Filed:
Dec 7, 2010
Appl. No.:
12/961671
Inventors:
John C. Somberg - Lake Forest IL, US
Vasant V. Ranade - Lake Bluff IL, US
Vasant V. Ranade - Lake Bluff IL, US
International Classification:
A01N 43/42, A61K 31/44, C07D 513/02, C07D 515/02
US Classification:
514300, 546114
Abstract:
Described herein are ways to solubilize clopidogrel for parenteral administration containing clopidogrel and a diluent NNDMA (N,N-dimethylacetamide); useful in the prevention of platelet aggregation in acute coronary syndrome, acute myocardial infarction or to prevent platelet facilitated thrombosis following coronary angioplasty and/or coronary stenting.
Methadone Chiral Isolate As An Improved Pharmaceutical
US Patent:
2013021, Aug 22, 2013
Filed:
Jun 20, 2012
Appl. No.:
13/528365
Inventors:
John C. Somberg - Lake Bluff IL, US
Vasant Ranade - Lake Bluff IL, US
Vasant Ranade - Lake Bluff IL, US
Assignee:
ACADEMIC PHARMACEUTICALS INCORPORATED - Lake Bluff IL
International Classification:
A61K 31/137
US Classification:
514648
Abstract:
The present invention relates to a method for treating drug addiction or neuropathic pain in a patient known to be vulnerable to life threatening cardiac arrhythmias (e.g., abnormally prolonged QT intervals, potassium chanelopathies, hypokalemia, or a combination thereof) by administering the R isolate of methadone to the patient.
Chiral Separation, Characterization And Biological Action Of Optically Active Isomers Of Digoxin
US Patent:
2006006, Mar 30, 2006
Filed:
Sep 29, 2004
Appl. No.:
10/951900
Inventors:
John Somberg - Lake Forest IL, US
Vasant Ranade - Libertyville IL, US
Vasant Ranade - Libertyville IL, US
International Classification:
C07J 17/00, A61K 31/704
US Classification:
514026000, 536006100
Abstract:
Disclosed herein is the method for separation of enantiomers or isomers of digoxin. These isomers are to be used in the treatment of heart failure without adverse or unneeded cardiac actions in humans. Additionally what is claimed is an isolate with less or no cardiac contractile effect but with AV node slowing such that the composition would be an effective therapy for the control of the ventricular response in atrial fibrillation. Also disclosed are methods for assaying these isomeric compounds present in biological fluids to enable the separation of pharmacologic actions.