JOHN BURTON MCLEAN
Architects in San Francisco, CA
License number
Pennsylvania RA008606B
Category
Architects
Type
Registered Architect
Address
Address
2
San Francisco, CA 94107
Pennsylvania
Pennsylvania
Personal information
See more information about JOHN BURTON MCLEAN at radaris.comName
Address
Phone
4813 Canehill Ave, Lakewood, CA 90713
5081 Norris St, Irvine, CA 92604
460 Running Brook Rd, North Wales, PA 19454
4686 Madrid Way #42C, Huntingtn Bch, CA 92649
45 S Mount Vernon Rd, Gap, PA 17527
Professional information
Host Cells And Method Of Producing Soluble Analogues Of Integrins
US Patent:
5726037, Mar 10, 1998
Filed:
May 19, 1995
Appl. No.:
8/444792
Inventors:
Sarah C. Bodary - San Francisco CA
Cornelia M. Gorman - San Francisco CA
John W. McLean - San Francisco CA
Mary A. Napier - Hillsborough CA
Cornelia M. Gorman - San Francisco CA
John W. McLean - San Francisco CA
Mary A. Napier - Hillsborough CA
Assignee:
Genentech, Inc. - San Francisco CA
International Classification:
C12N 510, C12N 1512
US Classification:
435 691
Abstract:
Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
Construction Professional
Location:
San Francisco Bay Area
Industry:
Construction
Education:
kailua high 1968 - 1972
Beta-8 Integrin Subunit Antibodies
US Patent:
5635601, Jun 3, 1997
Filed:
May 30, 1995
Appl. No.:
8/454455
Inventors:
Matthew Moyle - Walnut Creek CA
John W. McLean - San Francisco CA
John W. McLean - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
A61K 39395, C07K 1628, C12P 2108, C12N 1506
US Classification:
5303882
Abstract:
The cDNA encoding a novel beta integrin subunit, called the beta-8 integrin subunit, has been isolated from rabbit and human tissue and sequenced. Provided herein is nucleic acid sequence of the beta-8 integrin subunit useful as a diagnostic and in the recombinant preparation of beta-8 integrin subunit and alpha-beta integrin complexes. The beta-8 integrin subunit is used in the preparation and purification of antibodies thereto, and in diagnostic assays.
Soluble Analogues Of Integrins
US Patent:
5726290, Mar 10, 1998
Filed:
May 19, 1995
Appl. No.:
8/445042
Inventors:
Sarah C. Bodary - San Francisco CA
Cornelia M. Gorman - San Francisco CA
John W. McLean - San Francisco CA
Mary A. Napier - Hillsborough CA
Cornelia M. Gorman - San Francisco CA
John W. McLean - San Francisco CA
Mary A. Napier - Hillsborough CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C07K 14705, C07K 1900
US Classification:
530350
Abstract:
Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.
Method And Nucleic Acid For The Preparation Of Lecithin:cholesterol Acyltransferase
US Patent:
5049488, Sep 17, 1991
Filed:
Nov 8, 1985
Appl. No.:
6/796473
Inventors:
Bradford W. Baer - Menlo Park CA
Dennis T. Drayna - San Francisco CA
Richard M. Lawn - San Francisco CA
John W. McLean - San Francisco CA
Dennis T. Drayna - San Francisco CA
Richard M. Lawn - San Francisco CA
John W. McLean - San Francisco CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12Q 168
US Classification:
435 6
Abstract:
Nucleic acid encoding lecithin:cholesterol acyltransferase is ligated into expression vectors and used to transform host cells for the synthesis of lecithin:cholesterol acyltransferase in recombinant cell culture. Lecithin:cholesterol acyltransferase amino acid sequence variants are described for enhancing the properties of lecithin:cholesterol acyltransferase. Lecithin:cholesterol acyltransferase and its variants are employed in the therapy of conditions characterized by hypercholesterolemia and for the mobilization of cholesterol in vivo.
Method For Preparing Soluble Analogues Of Integrins
US Patent:
5837486, Nov 17, 1998
Filed:
May 19, 1995
Appl. No.:
8/445443
Inventors:
Sarah C. Bodary - San Francisco CA
Cornelia M. Gorman - San Francisco CA
John W. McLean - San Francisco CA
Mary A. Napier - Hillsborough CA
Cornelia M. Gorman - San Francisco CA
John W. McLean - San Francisco CA
Mary A. Napier - Hillsborough CA
Assignee:
Genentech, Inc. - South San Francisco CA
International Classification:
C12N 1512
US Classification:
435 691
Abstract:
Methods are provided for the preparation in recombinant host cells of biologically active soluble variants of discretely encoded, heteromultimer polypeptide receptors. Such variants are synthesized by the secretion from recombinant transformants of transmembrane-modified heteromultimer receptors. Preferred receptors are extracellular matrix, cell surface, or plasma protein-binding receptors such as GPIIb-IIIa.