JOHN BUEHLER
Pharmacy in Blue Bell, PA
License number
Pennsylvania RP023577L
Category
Pharmacy
Type
Pharmacist
Address
Address
Blue Bell, PA 19422
Professional information
Compositions Containing Opioid Antagonists
US Patent:
2014005, Feb 27, 2014
Filed:
Nov 1, 2013
Appl. No.:
14/070287
Inventors:
John D. BUEHLER - Blue Bell PA, US
Assignee:
Adolor Corporation - Lexington MA
International Classification:
A61K 31/451
US Classification:
514331
Abstract:
Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
Compositions Containing Opioid Antagonists
US Patent:
8598207, Dec 3, 2013
Filed:
May 22, 2012
Appl. No.:
13/477742
Inventors:
John D. Buehler - Blue Bell PA, US
Assignee:
Adolor Corporation - Lexington MA
International Classification:
A61K 31/454
US Classification:
514326, 514184, 514619, 514646, 514649, 514656
Abstract:
Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.
Compositions Containing Opioid Antagonists
US Patent:
2010024, Sep 23, 2010
Filed:
Mar 22, 2010
Appl. No.:
12/728622
Inventors:
John D. Buehler - Blue Bell PA, US
Assignee:
Adolor Corporation - Exton PA
International Classification:
A61K 31/451, A61K 31/454, A61K 31/485, A61K 31/473, A61K 31/4545, A61K 31/4535, A61P 25/04, A61P 17/04, A61P 1/00, A61P 1/08, A61P 1/06
US Classification:
514282, 514331, 514326, 514289, 514329, 514330, 514295, 514318
Abstract:
Compositions containing opioid antagonists, particularly alvimopan and its active metabolite, with improved solubility and bioavailability for oral or parenteral administration, injectable dosage formulations, kits, and methods of making and using same are disclosed. In preferred embodiments, invention provides injectable formulations containing opioid antagonists, particularly alvimopan and its active metabolite, having low solubility that may be readily prepared, are stable during storage, and provide maximum levels of opioid antagonists when administered parenterally, particularly via injection. The results are achieved by a combination of processing techniques and component selection.