JOHN ANTHONY GROSSO
Pilots at Newport Dr, W Windsor Township, NJ
License number
New Jersey A0733384
Issued Date
Apr 2015
Expiration Date
Apr 2017
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
22 Newport Dr, W Windsor Township, NJ 08550
Professional information
Method For Preparing Phosphinic Acids Used In Preparing Ace Inhibitors And Intermediates Produced Thereby
US Patent:
4873356, Oct 10, 1989
Filed:
Sep 30, 1987
Appl. No.:
7/102694
Inventors:
Edward W. Petrillo - Pennington NJ
Donald S. Karanewsky - East Windsor NJ
John K. Thottathil - Lawrenceville NJ
James E. Heikes - East Windsor NJ
John A. Grosso - Princeton Junction NJ
Donald S. Karanewsky - East Windsor NJ
John K. Thottathil - Lawrenceville NJ
James E. Heikes - East Windsor NJ
John A. Grosso - Princeton Junction NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07F 932
US Classification:
558180
Abstract:
A method is provided for preparing phosphinic acid compounds, which are useful in preparing certain angiotensin converting enzyme inhibitors, which have the formula ##STR1## wherein R. sub. 1 is lower alkyl, aryl, arylalkyl, cycloalkyl or cycloalkylalkyl;
R. sub. 2 is hydrogen, lower alkyl or arylalkyl;
X is hydrogen, lower alkyl or phenyl;
Y is hydrogen, lower alkyl, phenyl or alkoxy, or together X and Y are --(CH. sub. 2). sub. 2 --, --(CH. sub. 2). sub. 3 --, --CH. dbd. CH--, or ##STR2## and n is 0 or 1
including salts thereof and stereoisomers thereof, which method includes the steps of reacting a phosphinic acid ester of the structure ##STR3## wherein R. sub. 3 is a group removable by hydrogenolysis such as benzyl or substituted benzyl, with a halo ester of the structure ##STR4## in the presence of an organic base to form a phosphinic acid ester of the structure ##STR5## hydrogenating the above ester to form a diastereomic mixture of a phosphinic acid of the structure ##STR6## recrystallizing to recover the preferred racemic mixture and resolving same employing a resolving agent, preferably L-cinchonidine, to form the corresponding resolved salt which may be acidified to the corresponding acid. In addition, novel intermediates which are acids and salts as described above are also provided.
Method For Preparing Pyrrolotriazine Compounds Via In Situ Amination Of Pyrroles
US Patent:
7534882, May 19, 2009
Filed:
Apr 3, 2006
Appl. No.:
11/396888
Inventors:
Apurba Bhattacharya - Hyderabad, IN
Nitinchandra Patel - Gujarat, IN
John Anthony Grosso - Princeton Junction NJ, US
Luca Parlanti - Princeton NJ, US
Nitinchandra Patel - Gujarat, IN
John Anthony Grosso - Princeton Junction NJ, US
Luca Parlanti - Princeton NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 487/04, C07D 207/30, C07D 207/50
US Classification:
544183, 548530, 548557
Abstract:
A method for aminating pyrrole derivatives via in situ generated chloramines and for preparing pyrrolotriazine compounds having the formula III,.
Methods For The Preparation Of Pyrrolotriazine Compounds Useful As Kinase Inhibitors
US Patent:
7211666, May 1, 2007
Filed:
Dec 22, 2004
Appl. No.:
11/019788
Inventors:
John Hynes, Jr. - Washington Crossing PA, US
Alaric J. Dyckman - Lawrenceville NJ, US
Katerina Leftheris - Skillman NJ, US
Zhongping Shi - West Windsor NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Wendel William Doubleday - Doylestown PA, US
John A. Grosso - Princeton Junction NJ, US
Alaric J. Dyckman - Lawrenceville NJ, US
Katerina Leftheris - Skillman NJ, US
Zhongping Shi - West Windsor NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Wendel William Doubleday - Doylestown PA, US
John A. Grosso - Princeton Junction NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D 487/04, C07D 207/36
US Classification:
544183, 548538, 548587
Abstract:
Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I):.
Methods For The Preparation Of Biphenyl Isoxazole Sulfonamides
US Patent:
6313308, Nov 6, 2001
Filed:
Mar 20, 2000
Appl. No.:
9/528819
Inventors:
Ambarish Singh - Bordentown NJ
Chien-Kuang Chen - Marlboro NJ
John A. Grosso - Princeton Jct NJ
Edward J. Delaney - Princeton NJ
Xuebao Wang - East Brunswick NJ
Richard P. Polniaszek - Dayton NJ
John K. Thottathil - Princeton NJ
Chien-Kuang Chen - Marlboro NJ
John A. Grosso - Princeton Jct NJ
Edward J. Delaney - Princeton NJ
Xuebao Wang - East Brunswick NJ
Richard P. Polniaszek - Dayton NJ
John K. Thottathil - Princeton NJ
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D26116, C07D41312
US Classification:
548235
Abstract:
Methods for the preparation of biphenyl isoxazole sulfonamides and intermediates therof. The present invention also relates to the novel intermediates prepared by these methods. The biphenyl isoxazole sulfonamides prepared by the present methods are endothelin antagonists useful, inter alia, for the treatment of hypertension, congestive heart failure and male erectile dysfunction.
Selective Processes For Fosinopril Polymorphs
US Patent:
5162543, Nov 10, 1992
Filed:
Feb 16, 1990
Appl. No.:
7/481009
Inventors:
John A. Grosso - Princeton Junction NJ
Assignee:
E. R. Squibb & Sons, Inc. - Princeton NJ
International Classification:
C07F 9572
US Classification:
548413
Abstract:
Described herein is a process for selectively preparing and interconverting polymorph salts of fosinopril, an antihypertensive agent that inhibits angiotensin converting enzyme. Each polymorph is prepared by mixing an alkali metal carrier, fosinopril, water and a keto and/or hydroxylic solvent and isolating the polymorph formed from the reaction mixture. The less exothermic polymorph A is formed when the water makes up more than about 0. 2% of the water and solvents; at about 0. 2% or less, the more exothermic polymorph B is formed.
Methods For The Preparation Of Pyrrolotriazine Compounds Useful As Kinase Inhibitors
US Patent:
6867300, Mar 15, 2005
Filed:
Nov 6, 2002
Appl. No.:
10/289010
Inventors:
John Hynes, Jr. - Washington Crossing PA, US
Alaric J. Dyckman - Lawrenceville NJ, US
Katerina Leftheris - Skillman NJ, US
Zhongping Shi - West Windsor NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Wendel William Doubleday - Doylestown PA, US
John A. Grosso - Princeton Junction NJ, US
Alaric J. Dyckman - Lawrenceville NJ, US
Katerina Leftheris - Skillman NJ, US
Zhongping Shi - West Windsor NJ, US
Stephen T. Wrobleski - Whitehouse Station NJ, US
Wendel William Doubleday - Doylestown PA, US
John A. Grosso - Princeton Junction NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07D487/04, A61K031/53, A61P019/02, A61P011/06, A61P019/10
US Classification:
544183
Abstract:
Methods of preparing kinase inhibiting pharmaceutical compounds having the formula (I):
or a pharmaceutically acceptable salt or solvate thereof, wherein Rthrough Rand Z are as described in the specification. The methods according to the invention utilize an amination process, in which a pyrrole is reacted with a haloamine, preferably chloramine. This step is followed by cyclization to form the pyrrolotriazine core.
Crystal Structures Of Sglt2 Inhibitors And Processes For Preparing Same
US Patent:
7919598, Apr 5, 2011
Filed:
Jun 20, 2007
Appl. No.:
11/765481
Inventors:
Jack Z. Gougoutas - Princeton NJ, US
Hildegard Lobinger - Regensburg, DE
Srividya Ramakrishnan - Milltown NJ, US
Prashant P. Deshpande - Princeton NJ, US
Jeffrey T. Bien - Princeton NJ, US
Chiajen Lai - Kendall Park NJ, US
Chenchi Wang - Somerset NJ, US
Peter Riebel - Ruhstorf a.d. Rott, DE
John Anthony Grosso - Princeton Junction NJ, US
Alexandra A. Nirschl - Yardley PA, US
Janak Singh - Lawrenceville NJ, US
John D. DiMarco - East Brunswick NJ, US
Hildegard Lobinger - Regensburg, DE
Srividya Ramakrishnan - Milltown NJ, US
Prashant P. Deshpande - Princeton NJ, US
Jeffrey T. Bien - Princeton NJ, US
Chiajen Lai - Kendall Park NJ, US
Chenchi Wang - Somerset NJ, US
Peter Riebel - Ruhstorf a.d. Rott, DE
John Anthony Grosso - Princeton Junction NJ, US
Alexandra A. Nirschl - Yardley PA, US
Janak Singh - Lawrenceville NJ, US
John D. DiMarco - East Brunswick NJ, US
Assignee:
Bristol-Myers Squibb Company - Princeton NJ
International Classification:
C07H 7/04, C07H 1/00, A61K 31/70
US Classification:
536 111, 536124, 514 23
Abstract:
The present invention relates to physical crystal structures of a compound of the formula I:.
Method Of Preparation Of Nitroaminopyridine Compounds
US Patent:
2007003, Feb 8, 2007
Filed:
Jul 25, 2006
Appl. No.:
11/492730
Inventors:
Prashant Deshpande - Princeton NJ, US
John Grosso - Princeton Junction NJ, US
Apurba Bhattacharya - Hyderabad, IN
Vikram Purohit - College Station TX, US
John Grosso - Princeton Junction NJ, US
Apurba Bhattacharya - Hyderabad, IN
Vikram Purohit - College Station TX, US
International Classification:
C07D 213/72
US Classification:
546307000
Abstract:
A method of preparing an intermediate
which is useful for the preparation of azaindole derivatives.