Inventors:
Joshua Spector Tullis - Broomfield CO
John Charles Van Rens - Cincinnati OH
Michael Philip Clark - Loveland OH
Benjamin Eric Blass - Cincinnati OH
Michael George Natchus - Alpharetta GA
Biswanath De - Cincinnati OH
Assignee:
The Procter Gamble Company - Cincinnati OH
International Classification:
C07D40104
Abstract:
The present invention relates to 4-aryl triazoles having the formula: wherein R is independently selected from the group consisting of: lower alkyl, lower alkenyl, lower alkynyl, lower heteroalkyl, lower heteroalkenyl, lower heteroalkynyl, heterocycloalkyl, heteroaryl, halo, CN, OR , SR , S(O)R , S(O) R , and NR R ; and Q is has the general formula: said compounds are useful in treating diseases associated with unwanted cytokine activity, inter alia, interleukin-1 (IL-1) and tumor necrosis factor (TNF) from cells.