JOHN ALSTON KELLUM
Medical Practice in Pittsburgh, PA

2013029, Nov 14, 2013

Jul 18, 2013

13/945477

John A. Kellum - Pittsburgh PA, US

G01N 33/543, A61M 1/14

210645, 436501, 435 792

This invention is related to the field of the prevention and treatment of kidney disease. The treatment of kidney disease may be tailored depending upon the need for, or expectation of, long-term dialysis. For example, prediction of long-term dialysis treatment can be determined by monitoring urine biomarkers related to the development of chronic kidney disease. For example, a normalized time course of hyaluronic acid can be used to determine whether a patient having suffered acute kidney injury will require long-term dialysis.

2013025, Sep 26, 2013

Sep 23, 2011

13/825675

Joseph Anderberg - Encinitas CA, US
Jeff Gray - Solana Beach CA, US
Paul McPherson - Encinitas CA, US
Kevin Nakamura - Cardiff by the Sea CA, US
James Patrick Kampf - San Diego CA, US
Kai Singbartl - Pttsburgh PA, US
John A. Kellum - Pittsburgh PA, US

Astute Medical, Inc. - San Diego CA

G01N 33/53

435 792, 436501, 435 79

The present invention relates to methods and compositions for monitoring, diagnosis, prognosis, and determination of treatment regimens in subjects suffering from or suspected of having a renal injury. In particular, the invention relates to using assays that detect one or more of hyaluronic acid (HA) as diagnostic and prognostic biomarker assays in renal injuries.

8647666, Feb 11, 2014

Oct 2, 2009

13/122223

John A. Kellum - Pittsburgh PA, US
Mitchell P. Fink - Los Angeles CA, US

University of Pittsburgh—Of the Commonwealth System of Higher Education - Pittsburgh PA

A61K 9/48, A61K 9/14, A61K 9/16, A61K 31/74, A61K 31/00

424451, 424489, 424497, 424 7832, 424 7831, 424400

The invention provides a method of ameliorating systemic inflammation in a patient involving administering to the patient a therapeutically effective dose of composition including polystyrene divinyl benzene copolymer and a polyvinyl pyrrolidone polymer. More particularly, the method relates to using these polymers as an enteral sorbent preparation to remove inflammatory mediators, such as cytokines, from the intestinal lumen. The polymers can be in the form of a preparation of polystyrene divinyl benzene copolymer beads with a biocompatible polyvinyl pyrrolidone polymer coating.

2012020, Aug 9, 2012

Oct 7, 2010

13/500163

William J. Federspiel - Pittsburgh PA, US
John Alston Kellum - Pittsburgh PA, US
Kai Singbartl - Pittsburgh PA, US

A61K 35/12, A61P 37/00, A61M 1/00, A61P 35/00, A61P 9/00, A61K 35/14, A61P 29/00

424 9371, 424 937, 422 44

A method of modifying cells includes removing fluid including cells from a patient, contacting the removed fluid from the patient with at least one surface upon which at least one agent to interact at least one cell receptor is immobilized to modify cells in the fluid, and returning the fluid to the patient. The agent can, for example, be immobilized via covalent bonding or ionic bonding to the at least one surface. The fluid can, for example, be blood or a blood fraction. The agent can, for example, be an agonist, an antagonist or an inverse agonist.

2013019, Aug 1, 2013

Mar 14, 2013

13/804989

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA, US
John A. Kellum - Pittsburgh PA, US
William D. Anderson - Pittsburgh PA, US
Catalin Toma - Pittsburgh PA, US

University of Pittsburgh - Of the Commonwealth System of Higher Education - Pittsburgh PA

A61M 1/34, A61M 25/10, A61M 25/00

604 504, 604523, 604 9601

In one aspect, the invention provides a device comprising a catheter. In another aspect, the invention provides a method of removing an agent from blood.