Inventors:
Yulei WANG - Foster City CA, US
Catalin Barbacioru - Fremont CA, US
Raymond R. Samaha - Soquel CA, US
John A. Elefteriades - New Haven CT, US
Assignee:
Applied BioSystems, LLC - Carlsbad CA
International Classification:
C40B 30/04, A61F 2/06, C12Q 1/68
Abstract:
We hypothesized that gene expression patterns in peripheral blood cells may correlate with TAA disease status, and carried out a comprehensive gene expression survey on peripheral blood cells obtained from TAA patients and normal individuals. A distinct gene expression profile in peripheral blood cells can classify TAA patients from normal individuals. The genes provided by the present teachings define a set of diagnostic markers, thus providing a blood-based gene expression test to facilitate early detection of TAA disease. Methods of distinguishing ascending from descending TAA are also provided, as are methods of distinguishing familial from sporadic TAA.