Inventors:
Johannes L. Zakrzewski - New York NY, US
Marcel R.m. Van Der Brink - New York NY, US
Michael Sadelain - New York NY, US
Assignee:
MEMORIAL SLOAN-KETTERING CANCER CENTER - New York NY
International Classification:
A61K 35/12, A61P 35/00, A61P 35/02, A61P 37/02, A61P 3/00
Abstract:
The inventive subject matter relates to methods for treating a T-cell deficiency in a subject in need thereof, comprising administering to said subject a T-cell precursor isolated from an allogeneic donor, provided that said allogeneic donor is not MHC-matched to said subject. The inventive methods can be further enhanced by genetic engineering for targeted immunotherapy.