JOEL STEVEN GREENBERGER
Medical Practice in Sewickley, PA

6387366, May 14, 2002

Dec 31, 1998

09/224048

David R. Hurwitz - Boston MA
Van Cherington - Harvard MA
Theofanis Galanopoulos - Arlington MA
Peter H. Levine - Worcester MA
Joel S. Greenberger - Sewickley PA

ALG Company - Marlboro MA

A01N 6300

424 931, 424 932, 4241301, 424 9321, 514 44, 435325

The methods of the present invention are based on the discovery that adverse side effects (such as hemorrhage) can occur upon infusion of cells that express tissue factor. Accordingly, the methods of the invention are aimed at reducing the biological activity of tissue factor (TF) in a patient, and can be carried out by, for example: infusing fewer cells (or infuse the same number of BMSCs over a longer period of time); reducing the expression or activity of TF (within the infused cells specifically (e. g. , by contacting the cells with a TF antagonist in vitro) or within the patient generally (e. g. , by administering a TF antagonist to the patient); hampering the interaction of TF with factor VII(a); inhibiting the activity of the TF-factor VII(a) complex once it has formed; or inhibiting the coagulation cascade at any point downstream from formation of the complex (including inhibition of platelet activation).

6221848, Apr 24, 2001

May 11, 1998

9/075532

Joel S. Greenberger - Sewickley PA

University of Pittsburgh - Pittsburgh PA

A01N 4304, A01N 6300, C12N 1500, C12N 1563, C07G 1700

514 44

A method of protecting a subject against an agent that elicits production of toxic free radicals, superoxide anions, or heavy metal cations in the subject is disclosed which entails in vivo administration to the subject of a polynucleotide encoding a protein that is transiently expressed in said subject. The transiently expressed protein is capable of neutralizing or eliminating the toxic free radicals, superoxide anions or heavy metal cations that are elicited by the agent. The method is particularly useful in preventing the development of esophagitis during treatment of lung cancer patients with ionizing radiation and/or chemotherapeutic drugs.

6887856, May 3, 2005

Aug 6, 1997

08/907041

Joel S. Greenberger - Sewickley PA, US

University of Pittsburgh - Pittsburgh PA

A01N043/04, A01N063/00, C12N015/00, C12N015/63, C07G017/00

514 44, 435267, 4353201, 435455, 424 932, 424 9321

A method of protecting a subject against an agent that elicits production of toxic free radicals, superoxide anions, or heavy metal cations in the subject is disclosed which entails in vivo administration to the subject of a polynucleotide encoding a protein that is transiently expressed in said subject. The transiently expressed protein is capable of neutralizing or eliminating the toxic free radicals, superoxide anions or heavy metal cations that are elicited by the agent. The method is particularly useful in protecting cancer patients against the damaging effects of ionizing radiation and chemotherapeutic drugs. A composition useful in carrying out the method also is disclosed.

5823192, Oct 20, 1998

Jul 31, 1996

8/690521

Andre M. Kalend - Monroeville PA
Joel Greenberger - Sewickley PA
Karun B. Shimoga - Pittsburgh PA
Charalambos N. Athanassiou - Pittsburgh PA
Takeo Kanade - Pittsburgh PA

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

A61G 1500

128845

A patient is automatically accurately positioned relative to a fixed refece of a treatment/diagnostic device by an optical system which operates a patient positioning assembly to bring fiducials or skin markers on the patient into coincidence with impingement points of laser beams projected in a fixed pattern relative to the device. Cameras record images of the fiducials and laser impingement points from which alignment error and velocity error in pixel space are determined. The velocity error in pixel space is converted to a velocity error in room space by the inverse of an Image Jacobian. The Image Jacobian is initially derived using rough values for system parameters and is continuously updated and refined using the calculated errors in pixel space derived from the camera images and errors in room space derived from position encoders on the treatment/diagnostic device.

5727554, Mar 17, 1998

Sep 19, 1996

8/715834

Andre M. Kalend - Monroeville PA
Joel Greenberger - Sewickley PA
Karun B. Shimoga - Pittsburgh PA
Charalambos N. Athanassiou - Pittsburgh PA
Takeo Kanade - Pittsburgh PA

University of Pittsburgh of the Commonwealth System of Higher Education - Pittsburgh PA

A61B 600

1286531

A camera generates digital image signals representing an image of one or more natural or artificial fiducials on a patient positioned on treatment or diagnosis equipment. A processor applies multiple levels of filtering at multiple levels of resolution to repetitively determine successive fiducial positions. A warning signal is generated if movement exceeds certain limits but is still acceptable for treatment. Unacceptable displacement results in termination of the treatment beam. Tracking templates can be generated interactively from a display of the digital image signals or through automatic selection of an image having the median correlation to an initial template. A gating signal synchronized to patient breathing can be extracted from the digital image signals for controlling the radiation beam generator.

6008010, Dec 28, 1999

Nov 1, 1996

8/741628

Joel S. Greenberger - Sewickley PA
Paul A. DiMilla - Gibsonia PA
Michael M. Domach - Pittsburgh PA
Raymond K. Houck - Oakmont PA

University of Pittsburgh - Pittsburgh PA

C12P 100, C12N 100, A01N 102, C12M 100

435 41

The present invention pertains to an apparatus for holding cells. The apparatus comprises a mechanism for incubating cells having a dynamically controlled closed environment in which the cells are grown, which are maintained in a desired condition and in which cells can be examined while the environment is dynamically controlled and maintained in the desired condition. The apparatus also comprises a mechanism for determining the state of the cells. The determining mechanism is in communication with the incubating mechanism. The present invention pertains to a method for holding cells. The method comprises the steps of incubating the cells in a dynamically controlled closed environment which is maintained in a desired condition and in which the cells can be examined while the environment is dynamically controlled and maintained in the desired condition. Additionally, there is the step of determining the state of the cells.

2012020, Aug 16, 2012

Jan 12, 2012

13/349526

Joel S. Greenberger - Sewickley PA, US
Peter Wipf - Pittsburgh PA, US

A61K 31/445, A61P 17/00, A61Q 17/04, A61K 8/49

424 59, 514315

A method for preventing or treating skin damage in a radiotherapy subject, comprising topically administering to the subject a composition that includes a therapeutically effective amount at least one targeted nitroxide agent and at least one additional ingredient.

2011028, Nov 24, 2011

Oct 21, 2009

13/124924

Michael Epperly - McCandless PA, US
Joel Greenberger - Sewickley PA, US
Jianfei Jiang - Pittsburgh PA, US
Valerian Kagan - Pittsburgh PA, US
John Lazo - Pittsburgh PA, US
Peter McDonald - Lawrence KS, US

A61K 31/17, A61P 39/00

514593

Provided herein are methods, for reducing, preventing, mitigating and treating damage caused by radiation. The methods comprise delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation or to mitigate apoptosis. The compounds comprise glyburide or other sulfonylurea hypoglycemic compounds or potassium channel inhibitors.

5599712, Feb 4, 1997

Oct 15, 1993

8/136079

Joel S. Greenberger - Sewickley PA

University of Pittsburgh - Pittsburgh PA

A61K 4800, C12N 1500

435267

A method of protecting a subject against an agent that elicits production of toxic free radicals, superoxide anions, or heavy metal cations in the subject consisting of the in vivo administration to the subject of a polynucleotide encoding a protein that is transiently expressed in said subject. The transiently expressed protein is capable of neutralizing or eliminating the toxic free radicals, superoxide anions or heavy metal cations that are elicited by the agent. This method is particularly useful in protecting cancer patients against the damaging effects of ionizing radiation and chemotherapeutic drugs.

2011017, Jul 14, 2011

Jan 14, 2011

13/006640

Peter Wipf - Pittsburgh PA, US
Natalia A. Belikova - McDonald PA, US
Jianfei Jiang - Pittsburgh PA, US
Joshua Pierce - La Jolla CA, US
Joel Greenberger - Sewickley PA, US
Michael Epperly - Pittsburgh PA, US
Valerian Kagan - Pittsburgh PA, US

A61K 31/541, A61K 31/445, A61K 31/40, A61K 31/454, A61P 43/00

5142272, 514315, 514423, 514326

Provided herein are compositions and related methods useful for free radical scavenging, with particular selectivity for mitochondria. The compounds comprise a nitroxide-containing group attached to a mitochondria-targeting group. The compounds can be cross-linked into dimers without loss of activity. Also provided herein are methods, for preventing, mitigating and treating damage caused by radiation. The method comprises delivering a compound, as described herein, to a patient in an amount and dosage regimen effective to prevent, mitigate or treat damage caused by radiation.