Inventors:
Charles Grissom - Salt Lake City UT, US
Frederick West - Salt Lake City UT, US
James McGreevy - Salt Lake City UT, US
Joel Bentz - Salt Lake City UT, US
Michelle Cannon - Price UT, US
International Classification:
C12Q001/68, C07H023/00
Abstract:
The present invention relates to fluorescent cobalamins and uses of these compounds. More particularly, this invention relates to fluorescent cobalamins that comprise a fluorescent, phosphorescent, luminescent or light-producing compound covalently linked to cobalamin. These fluorescent cobalamins can be used to as diagnostic and prognostic markers (a) to distinguish cancer cells and tissues from healthy cells and tissues, including identifying lymph nodes containing cancer cells, and (b) to determine if an individual will respond positively to chemotherapy using cobalamin-therapeutic bioconjugates.