Inventors:
Joel S. Goldberg - Durham NC, US
Joe Brice Weinberg - Durham NC, US
International Classification:
A61K 31/765, A61K 31/225, C08G 63/06, G01N 33/566, A61P 35/00, C12N 5/09, C07C 69/68
US Classification:
424 7837, 435375, 514547, 560180, 435 71, 528361
Abstract:
The invention provides method for sequestering or trapping L-lactate in or near a tumor cell comprising contacting an isolated polymer of D-lactic acid (PDLA) or an equivalent, derivative or analog thereof with the tumor cell so that the PDLA binds L-lactate in or near the cell and thereby sequestering or trapping L-lactate in or near the tumor cells.