Inventors:
William F. DeGrado - Media PA, US
Meredith W. Miller - Philadelphia PA, US
Sandeep Basra - Munchen, DE
Joel S. Bennett - Bryn Mawr PA, US
Sungwook Choi - San Diego CA, US
International Classification:
A61K 31/40, C07D 207/16, C07D 211/60, C07D 217/26, C07D 215/48, C07D 277/06, C07D 263/06, A61K 31/397, A61K 31/445, A61K 31/472, A61K 31/47, A61K 31/426, A61K 31/421, A61P 9/00, A61P 9/10, A61P 3/10, A61P 35/00, A61P 31/12
US Classification:
51421017, 548537, 546225, 546143, 546159, 548200, 548215, 514423, 514329, 514309, 514312, 514365, 514374
Abstract:
Novel compounds inhibiting the integrin α2β1/GPIa-IIa receptor are disclosed. Also disclosed are pharmaceutical compositions containing the compounds, as well as methods of their therapeutic use. The compounds disclosed are useful, inter alia, as inhibitors of integrin α2β1/GPIa-IIa-mediated activity.