Inventors:
Arthur M. Krieg - Wellesley MA, US
Joel N. Kline - Iowa City IA, US
Assignee:
University of Iowa Research Foundation - Iowa City IA
International Classification:
A61K 39/00, A61K 39/38, A61K 45/00, A61K 47/00, A61K 9/127, A61K 9/52, A61K 9/16, A61K 9/50, A61K 31/70, A01N 25/08, A01N 43/04, A61F 13/00
US Classification:
514 44, 4241841, 4242821, 4242781, 424409, 424434, 424450, 424457, 424490
Abstract:
Nucleic acids containing unmethylated CpG dinucleotides and therapeutic utilities based on their ability to stimulate an immune response and to redirect a Th2 response to a Th1 response in a subject are disclosed. Methods for treating atopic diseases, including atopic dermatitis, are disclosed.