Inventors:
Joel D. Ernst - New York NY, US
Ludovic Desvignes - New York NY, US
International Classification:
A61K 31/196, C12Q 1/02, A61P 37/06, A61K 31/198, A61P 29/00, C12N 5/07, G01N 33/53
US Classification:
514564, 435375, 435 29, 435 792, 514567
Abstract:
The present invention provides methods for the modulation of T cells and T cell responses, particularly of Th17 effector cells. The invention provides methods of and compositions for modulating T cells, particularly T cells expressing IL-17, particularly Th17 effector cells, via the tryptophan metabolism pathway, particularly using tryptophan metabolites, kynurenines and kynurenine analogs or metabolites. The invention provides assays for screening Th17 modulators and kynurenine analogs or compounds.