Inventors:
Joel B. Portnoff - Langhorne PA
Royden M. Coe - Bordentown NJ
John Grimm - Schnecksville PA
Kenneth Raines - Bethlehem PA
Joel Bartholomew - Danielsville PA
Assignee:
The Liposome Company, Inc. - Princeton NJ
B. Braun Medical, Inc. - Bethlehem PA
International Classification:
G01N 110
Abstract:
A formulation preparation device is provided herein which contains a valve assembly, transfer spikes, syringe port and tube, these components being interconnected so as to provide for controlled fluid flow between the spikes and port, through the assembly, in specific directions only. The device has an enclosed, sterilizable, gripable housing and can be used to mix combine fluids in reproducible and predetermined proportions. Combination is accomplished aseptically, avoiding contact between the device's operator and the fluids and the substances combined. Biologically active compounds can be combined with one or more fluids, including such aqueous liposome suspensions, using the device. A formulation preparation kit containing, in addition to the device, the fluids and compounds to be formulated is thus also provided herein; methods of using the device to prepare such formulations are further provided herein.