Inventors:
Joe Weinberg - Durham NC, US
Marc Levesque - Durham NC, US
Dipak Ghosh - Durham NC, US
International Classification:
A61K031/573, A61K031/4172, A61K031/416, A61K031/381, A61K031/198
US Classification:
514171000, 514400000, 514406000, 514447000, 514565000
Abstract:
A method for inducing apoptosis or cell death in leukemia cells includes inhibiting the production of nitric oxide (NO) by using a nitric oxide synthase (NOS) inhibitor, or the actions of NO by a NO quencher/scavenger. The NOS inhibitor includes a NOS1-specific inhibitor, such as N-[4-(2-{[(3-chlorophenyl)methyl]amino}ethyl)phenyl]-2-thiophenecarboximide dihydrochloride, [N-(1-imino-3-butenyl)-L-ornithine], 7-nitroindazole, or 1-(2-trifluoromethylphenyl)imidazole. The examples of NO quencher/scavenger include 2-(4-carboxyphenyl)-4,4,5,5-tetramethylimidazoline-1-oxyl-3-oxide and hydroxocobalamin.