Inventors:
Jochen Reiser - Miami FL, US
Brian Adair - Malden MA, US
Assignee:
University of Miami - Miami FL
Massachusetts General Hospital - Boston MA
International Classification:
A61K 39/395, A61K 38/48, A61K 31/7088, A61K 38/02, A61K 38/43, C12Q 1/37, C12Q 1/02, C07K 14/47, C12N 15/63, C07K 16/18, C12N 9/00, C12N 9/64, C12N 9/14, A61P 13/12, A61P 3/10, A61P 7/00, A61P 35/00, A61P 31/00
US Classification:
4241581, 424 9465, 514 44 R, 514 202, 514 44 A, 514 11, 424 941, 435 23, 435 29, 530350, 4353201, 5303898, 5303879, 435183, 435226, 435195
Abstract:
Compositions which specifically block cathepsin L function in podocytes, compositions which protect cytoskeletal adaptor protein (CD2AP) for degradation, compositions which modulate expression or function of cytoskeletal adaptor protein (CD2AP), protect against renal diseases or disorders. Methods of treatment in vivo involve use of one or more compositions.