Inventors:
Josef Miller - Ann Arbor MI, US
Colleen LePrell - Ypsilanti MI, US
Jochen Schacht - Ann Arbor MI, US
Diane Prieskorn - Livonia MI, US
Assignee:
THE REGENTS OF THE UNIVERSITY OF MICHIGAN - Ann Arbor MI
International Classification:
A61K 33/06, A61P 27/00, A61K 31/355, A61K 31/58, A61K 31/07, A61K 31/375
US Classification:
424682, 514725, 514474, 514733, 514458, 514171
Abstract:
A composition for treating hearing loss includes components that function through different biological mechanisms to provide an additive effect that is equal to or greater than a sum of the effect of the individual components. The composition includes a biologically effective amount of at least one scavenger of singlet oxygen, a donor antioxidant, a third antioxidant, and a vasodilator. A method of treating hearing loss includes the step of internally administering the composition including a biologically effective amount of the at least one scavenger of singlet oxygen, the donor antioxidant, the third antioxidant, and the vasodilator to a mammal within three days of trauma to a middle or inner ear of the mammal.