Joan M Von Feldt
Physician in Wilmington, DE
License number
Delaware C1-0002387
Issued Date
Nov 1, 1983
Expiration Date
Mar 31, 2019
Category
Medical Practice
Type
Physician M.D.
Address
Address
2
Wilmington, DE 19803
Professional information
Methods Of Identifying Biologically Active Receptor-Binding Peptides
US Patent:
5837460, Nov 17, 1998
Filed:
Sep 3, 1996
Appl. No.:
8/712212
Inventors:
Joan M. Von Feldt - Wilmington DE
Thomas Kieber-Emmons - Newtown Square PA
David B. Weiner - Merion PA
William V. Williams - Havertown PA
Thomas Kieber-Emmons - Newtown Square PA
David B. Weiner - Merion PA
William V. Williams - Havertown PA
Assignee:
Trustees of the University of Pennsylvania - Philadelphia PA
The Wistar Institute - Philadelphia PA
The Wistar Institute - Philadelphia PA
International Classification:
C12Q 168, G01N 3353
US Classification:
435 6
Abstract:
A method of identifying peptides which mimic biologically active proteins is disclosed. The method comprises the steps of making a recombinant antibody library from genetic material obtained from an animal which has been immunized against antibodies that bind to the biological active protein to the mimicked. Recombinant antibodies are screened to identify antibodies which compete with the biological active protein. Peptides which comprise the recombinant antibody's CDR sequences are synthesized. Synthetic peptides which mimic GM-CSF are also disclosed.