Inventors:
Joan W. Berman - New York NY
Tina M. Calderon - Bronx NY
Assignee:
Albert Einstein College of Medicine of Yeshiva University, a Division of
Yeshiva University - Bronx NY
International Classification:
A61K 3516
Abstract:
This invention relates to a method for the prevention of monocyte adherence to the endothelial cells lining blood vessels, their subsequent invasion of surrounding tissues and diseases related thereto. It comprises inducing a monocyte adhesion protein to the surface of endothelial cells by treatment with specific cytokines, preparing a monoclonal antibody to the monocyte adhesion protein and contacting the antibody to the protein to form a complex. The monoclonal antibody does not bind to the cell surface proteins VCAM or ELAM. The complex results in a decrease in the adherence of monocytes to endothelial cells and thereby attenuates or prevents the harmful effects of monocyte invasion of endothelial cells and surrounding tissues.