Inventors:
Steven Ruben - Olney MD, US
Pablo Jimenez - Chatham NJ, US
Roxanne Duan - Bethesda MD, US
Mark Rampy - Montgomery Village MD, US
Donna Mendrick - Mount Airy MD, US
Jun Zhang - Bethesda MD, US
Jian Ni - Rockville MD, US
Paul Moore - Germantown MD, US
Timothy Coleman - Gaithersburg MD, US
Joachim Gruber - Elizabethtown KY, US
Patrick Dillon - Carlsbad CA, US
Reiner Gentz - Rockville MD, US
Assignee:
HUMAN GENOME SCIENCES, INC.
International Classification:
A61K048/00, A61K038/18, C12N005/08
US Classification:
514/044000, 514/012000, 435/366000
Abstract:
This invention relates to newly identified polynucleotides, polypeptides encoded by such polynucleotides, the use of such polynucleotides and polypeptides, as well as the production of such polynucleotides and polypeptides. More particularly, the polypeptide of the present invention is a Keratinocyte Growth Factor, sometimes hereinafter referred to as “KGF-2” also formerly known as Fibroblast Growth Factor 12 (FGF-12). This invention further relates to the therapeutic use of KGF-2 to promote or accelerate wound healing. This invention also relates to novel mutant forms of KGF-2 that show enhanced activity, increased stability, higher yield or better solubility.