Inventors:
Hugh A. Sampson - Greenwich CT, US
Jing Lin - Philadelphia PA, US
Ludmilla Bardina - New York NY, US
Assignee:
Mount Sinai School of Medicine of New York University - New York NY
International Classification:
C40B 30/04, C40B 40/10, C07K 7/08, C07K 14/00
US Classification:
506 9, 506 18, 530326, 530327, 530324, 530350
Abstract:
Methods for performing epitope mapping, and for characterizing the antibody binding affinity and epitope diversity of antibodies in a sample using peptide microarray are provided. In some aspects, methods are provided for the specific characterization of IgE and IgG4. Also disclosed are methods for diagnosing whether a milk-allergic individual will outgrow his or her allergy based on the characterization of the individual's milk allergen-specific IgE antibodies.