Inventors:
Jing Li - Flushing NY, US
David Mu - Jericho NY, US
Jianxin Yang - Commack NY, US
International Classification:
C12Q001/68, C07H021/04, C12P021/02, C12N005/06, A61K048/00, C07K014/705
US Classification:
435/006000, 435/069100, 435/320100, 435/325000, 530/350000, 514/044000, 536/023500
Abstract:
There are disclosed methods and compositions for the diagnosis, prevention, and treatment of tumors and cancers in mammals, for example, humans, utilizing the RecQL5, CTXL, USP13, MCL1, and Pellino1 genes, which are amplified in many types of cancer. The RecQL5, CTXL, USP13, MCL1, and Pellino1 genes, their expressed protein products and antibodies are used diagnostically or as targets for cancer therapy or as vaccines; they also are used to identify compounds and reagents useful in cancer diagnosis, prevention, and therapy.