JIMO BORJIGIN
Pharmacy in Ann Arbor, MI
License number
Michigan 5304000740
Issued Date
Jul 28, 2010
Expiration Date
Jun 30, 2017
Category
Pharmacy
Type
CS - Research Lab
Address
Address
Ann Arbor, MI 48109
Personal information
See more information about JIMO BORJIGIN at radaris.comName
Address
Phone
2080 E Delhi Rd, Ann Arbor, MI 48103
Ann Arbor, MI
2080 Delhi Rd, Scio Township, MI 48103
Professional information
Monitoring Circadian Activity
US Patent:
2005005, Mar 17, 2005
Filed:
Mar 31, 2004
Appl. No.:
10/812939
Inventors:
Jimo Borjigin - Ann Arbor MI, US
International Classification:
A61B017/16, A61K049/00
US Classification:
606080000, 424009100, 607088000
Abstract:
The invention is directed to a new method for long-term measurement of daily serotonin (5-HT) and melatonin contents in the pineal gland. The disclosed method allows visualization of the pineal gland for accurate targeting of the guide cannula which minimizes bleeding, incurs no direct injury to the surrounding brain tissue and cause no interference with the sympathetic innervation from the superior cervical ganglion. The improved method allows effects of pharmacological agents on in vivo pineal gland circulation to be studied reproducibly over time and gene expression profiles correlated with physiological consequences in the same or different individuals. More importantly, the method allows accurate assessment of the endogenous circadian clock function. The method can be used for high throughput screening to identify candidate agents which may accelerate adaptation to new time zones, to alleviate symptoms resulting from jet lag, frequent shift work sleep abnormalities and seasonal affective illnesses.