Inventors:
Mark L. Nelson - Norfolk MA, US
Roger Frechette - Reading MA, US
Peter Viski - Chestnut Hill MA, US
Mohamed Y. Ismail - Bedford MA, US
Todd Bowser - Charlton MA, US
Jimmy Dumornay - Tampa FL, US
Glen Rennie - South Weymouth MA, US
Gui Liu - Lexington MA, US
Darrell J. Koza - Willimantic CT, US
Paul Sheahan - Hopkinton MA, US
Karen Stapleton - Weymouth MA, US
Paul Hawkins - Santa Fe NM, US
Atul K. Verma - Mansfield MA, US
Laura Honeyman - London, CA
Tadeusz Warchol - Northborough MA, US
David Messersmith - Somerville MA, US
Assignee:
Trustees of Tufts College - Medford MA
Paratek Pharmaceuticals, Inc. - Boston MA
International Classification:
A61K 31/65, C07C 275/40, C07C 271/30, C07D 307/81, C07D 333/24, C07D 317/60, C07F 9/40, A61K 31/662, C07C 311/21, C07C 255/60, C07F 7/10, A61K 31/695, C07D 295/155, C07C 275/54, C07C 335/20, C07C 311/05, C07D 213/56, C07C 279/18, C07H 15/203, A61K 31/7034, A61P 31/04, A61P 35/00, C07D 213/64, C07C 237/26
US Classification:
514 25, 552205, 514152, 549469, 549 77, 549441, 514119, 514 63, 544380, 546285, 536 179
Abstract:
The present invention pertains, at least in part, to novel 9-substituted minocycline compounds. These minocycline compounds can be used to treat numerous tetracycline compound-responsive states, such as bacterial infections and neoplasms, as well as other known applications for minocycline and tetracycline compounds in general, such as blocking tetracycline efflux and modulation of gene expression.