Inventors:
Sarah L. GAFFEN - Amherst NY, US
Fang Shen - Amherst NY, US
Walter Hanel - Stony Brook NY, US
Jill Kramer - Glen Oaks NY, US
James P. Malone - Buffalo NY, US
Michael Wittekind - Bainbridge Island WA, US
Raymond Paxton - Bellevue WA, US
Assignee:
RESEARCH FOUNDATION OF THE STATE UNIVERSITY OF NEW YORK - Amherst NY
AMGEN INC. - Thousand Oaks CA
International Classification:
C07K 14/47
US Classification:
435358, 435325, 435363, 435364, 435369, 435419, 4352523, 43525233, 43525411, 4352572, 4352581, 4353201, 530324, 5303879, 536 234, 536 235, 536 2353
Abstract:
The invention provides isolated Pre-Ligand Assembly Domain (PLAD) polypeptides which inhibit multimerization of a receptor complex comprising an IL-17R family member. Related PLAD-binding polypeptides, chimeric proteins, conjugates, nucleic acids, vectors, host cells, and methods are provided herein.