DR. JEWELL LAVERNE OSTERHOLM, M.D.
Medical Practice at Huston Rd, Wayne, PA

4445514, May 1, 1984

Jun 18, 1981

6/275117

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

A61K 3100, A61M 514

128632

A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.

4795423, Jan 3, 1989

Aug 28, 1986

6/901640

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

A61M 3700

604 24

A novel method of treating ischemic retinopathy is disclosed. After diagnosis of ischemic retinopathy, as for example as a result of retinal infarction, the ocular globe is penetrated with two small cannulae. An inflow and outflow perfusion is then established with an oxygenated perfluorochemical emulsion or other physiologically compatible oxygenated liquid. A sufficient perfusion rate is established and maintained to provide the metabolic needs of the retina for the 3 to 5 day period necessary to permit the natural healing process to occur. The method comprises removing at least a portion of vitreous body to create an intraocular perfusion space and establishing a perfusion of physiologically compatible oxygenated fluid through that perfusion space at a rate and for a duration sufficient to permit the natural healing process to occur. Alternatively, a method of diagnosing the condition of retinal tissue suspected of being ischemic is disclosed.

4378797, Apr 5, 1983

Apr 14, 1980

6/139886

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

A61K 3100, A61M 514

604 24

A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagnosing the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.

4840617, Jun 20, 1989

Aug 24, 1988

7/238982

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

A61M 2502, A61M 500, A61M 100, A61B 1900

604174

A cerebral catheterization apparatus for delivering oxygenated nutrient to or from the cerebro-spinal fluid pathway of a patient suspected of suffering from ischemic central nervous system tissue is disclosed. The apparatus comprises catheter means for providing a delivery pathway for an oxygenated nutrient to the lateral ventricle of the brain, which delivery pathway comprises an inlet and outlet; guide means, mating with the catheter means, for directing the catheter means toward the lateral ventricle; and a harness, on which the guide means is mounted, which is positionable with respect to the patient's head such that the catheter means may be reliably inserted into the lateral ventricle.

4758431, Jul 19, 1988

Sep 30, 1982

6/428900

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

A61K 3320, A61K 3314, A61K 3306, A61K 31195

424149

A novel system and method for treating ischemic neurologic tissue is disclosed wherein an oxygenated nutrient emulsion is circulated through at least a portion of the cerebospinal pathway. The nutrient emulsion contains an oxygenatable non-aqueous component, an aqueous nutrient component, an emulsification component, and other components which render physiologic acceptability of the nutrient emulsion. Methods for producing the nutrient emulsion and a system for delivering that emulsion to the cerebrospinal pathway are also disclosed. Additionally, novel diagnostic methods for diagonising the physiologic state of hypoxic-ischemic and other diseased neurologic tissue during treatment are provided.

4608635, Aug 26, 1986

May 23, 1985

6/737239

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

G06F 1542

364414

A computer-assisted tomographic image is overlayed with the visual indication of any regions representing a deviation from a norm. The overlaid region may indicate a deviation of the radiodensity in that region. The overlaid region may also indicate a deviation from an electrophysiological norm based on compressed spectral analysis of an electroencephalographic signal or evoked potentials represented by such a signal.

4657532, Apr 14, 1987

Jul 19, 1985

6/757015

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

A61M 3700

604 24

A novel method of oxygenating the tissue of a living mammal is disclosed comprising the steps of providing an oxygenated fluorocarbon-containing liquid; injecting that oxygenated liquid into the peritoneal cavity of said mammal; and withdrawing said fluorocarbon liquid from said cavity, said injecting and withdrawing be conducted at a rate sufficient to oxygenate said tissue. Accordingly, a novel "artificial lung" is disclosed which is useful to selectively oxygenate the body of a mammal, as reflected by increased arterial blood gas (pO. sub. 2) in said mammal.

4532591, Jul 30, 1985

Aug 3, 1982

6/404898

Jewell L. Osterholm - Radnor PA

Thomas Jefferson University - Philadelphia PA

G06F 1542

364414

A computer-assisted tomographic image is overlayed with the visual indication of any regions representing a deviation from a norm. The overlaid region may indicate a deviation of the radiodensity in that region. The overlaid region may also indicate a deviation from an electrophysiological norm based on compressed spectral analysis of an electroencephalographic signal or evoked potentials represented by such a signal.

5085630, Feb 4, 1992

May 21, 1990

7/507361

Jewell L. Osterholm - Radnor PA
Glenn D. Frazer - Wynwood PA

Thomas Jefferson University - Philadelphia PA

A61M 100

604 28

The invention provides novel improved oxygenated fluorocarbon nutrient solutions for treatment of hypoxic-ischemic neurologic tissue in mammals. The invention also provides methods of making such nutrient solution and methods of administering them.