JESUS A MIRANDA
Medical Practice at 179 St, Hialeah, FL

5958446, Sep 28, 1999

May 4, 1995

8/433754

Jesus Miranda - Miami FL
Steven Sablotsky - Miami FL

Noven Pharmaceuticals, Inc. - Miami FL

A61F 1302

424448

The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.

6235306, May 22, 2001

Mar 23, 1999

9/274886

Jesus Miranda - Miami FL
Steven Sablotsky - Miami FL

Noven Pharmaceuticals, Inc. - Miami FL

A61F 1302

424448

The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.

6024976, Feb 15, 2000

Aug 11, 1997

8/907906

Jesus Miranda - Miami FL
Steven Sablotsky - Miami FL

Noven Pharmaceuticals, Inc. - Miami FL

A61F 1302

424449

A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.

5656286, Aug 12, 1997

Jan 7, 1994

8/178558

Jesus Miranda - Miami FL
Steven Sablotsky - Miami FL

Noven Pharmaceuticals, Inc. - Miami FL

A61F 1302

424449

A blend of at least two polymers, or at least one polymer and a soluble polyvinylpyrrolidone, in combination with a drug provides a pressure-sensitive adhesive composition for a transdermal drug delivery system in which the drug is delivered from the pressure-sensitive adhesive composition and through dermis when the pressure-sensitive adhesive composition is in contact with human skin. According to the invention, soluble polyvinylpyrrolidone can be used to prevent crystallization of the drug, without affecting the rate of drug delivery from the pressure-sensitive adhesive composition.

5474783, Dec 12, 1995

Jun 27, 1991

7/722342

Jesus Miranda - Miami FL
Steven Sablotsky - Miami FL

Noven Pharmaceuticals, Inc. - Miami FL

A61F 1302

424448

The method of adjusting the saturation concentration of a drug in a transdermal composition for application to the dermis, which comprises mixing polymers having differing solubility parameters, so as to modulate the delivery of the drug. This results in the ability to achieve a predetermined permeation rate of the drug into and through the dermis. In one embodiment, a dermal composition of the present invention comprises a drug, an acrylate polymer, and a polysiloxane. The dermal compositions can be produced by a variety of methods known in the preparation of drug-containing adhesive preparations, including the mixing of the polymers, drug, and additional ingredients in solution, followed by removal of the processing solvents. The method and composition of this invention permit selectable loading of the drug into the dermal formulation and adjustment of the delivery rate of the drug from the composition through the dermis, while maintaining acceptable shear, tack, and peel adhesive properties.

2004013, Jul 15, 2004

Mar 12, 2004

10/472598

Gregory Glenn - Poolesville MD, US
Jianmei Yu - Bethesda MD, US
Mervyn Hamer - Gaithersburg MD, US
Jesus Miranda - Miami FL, US
Christopher Adams - Miramar FL, US

A61K039/00, A61K039/38

424/184100

A protein-in-adhesive patch for transcutaneous immunization is described with at least four different components: (i) backing layer; (ii) pressure-sensitive adhesive adhering to the backing layer; (iii) at last one immunologically-active protein of an immunogenic formulation applied to the pressure-sensitive adhesive layer opposite the backing layer and/or incorporated in the pressure-sensitive adhesive layer such that the at least one protein is in contact with adhesive; and (iv) stabilizer which maintains the immunological activity of the at least one protein under ambient conditions.

6974588, Dec 13, 2005

Dec 7, 1999

09/456278

Jesus Miranda - Miami FL, US

Elan Pharma International Limited - Clare

A61F013/02, A61F013/00, A61L015/16

424448, 424449

A transdermal patch for administering a volatile liquid drug, such as nicotine, transdermally to a patient comprising a four-layer laminated composite of: a top drug impermeable backing layer; a pressure sensitive silicone adhesive layer containing the drug; a pressure sensitive acrylic adhesive layer also containing the drug; and a removable siliconized release liner layer. Also disclosed is a method for treating a person for nicotine dependence and particularly for treating a woman for nicotine dependence.