JERRY LEE THOMAS
Pilots at Hope Ave, Santa Barbara, CA
License number
California A2707692
Category
Airmen
Type
Authorized Aircraft Instructor
Address
Address
102 N Hope Ave APT 50, Santa Barbara, CA 93110
Professional information
Activatable Binding Polypeptides And Methods Of Identification And Use Thereof
US Patent:
2014004, Feb 13, 2014
Filed:
Jul 24, 2013
Appl. No.:
13/950174
Inventors:
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Jason Sagert - Santa Barbara CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Jason Sagert - Santa Barbara CA, US
Assignee:
CytomX Therapeutics, Inc. - South San Francisco CA
The Regents of the University of California - Oakland CA
The Regents of the University of California - Oakland CA
International Classification:
C07K 16/24
US Classification:
435 792, 435 696, 5303873
Abstract:
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Activatable Binding Polypeptides And Methods Of Identification And Use Thereof
US Patent:
2009030, Dec 10, 2009
Filed:
Aug 21, 2008
Appl. No.:
12/196269
Inventors:
Patrick Daugherty - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
International Classification:
A61K 39/395, C07K 2/00, C07K 14/00, C40B 30/04, C40B 40/10, C40B 40/02, C12N 15/11, C40B 50/06, A61K 38/16, C12P 21/06, G01N 33/53, C07K 16/00, A61K 49/00, C12N 9/68, C12N 9/50
US Classification:
4241781, 530300, 530350, 506 9, 506 18, 506 14, 536 231, 506 26, 514 12, 435 681, 435 71, 5303873, 424 91, 435217, 435219
Abstract:
The present disclosure provides activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM). The present disclosure provides activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM. Furthermore the present disclosure also provides ABPs which contain a first TBM, a second TBM and a CM. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. The disclosure further provides libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. The disclosure further provides ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Activatable Binding Polypeptides And Methods Of Identification And Use Thereof
US Patent:
8541203, Sep 24, 2013
Filed:
Mar 2, 2012
Appl. No.:
13/411416
Inventors:
Patrick Sean Daugherty - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
James W. West - Santa Barbara CA, US
Jason Sagert - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
James W. West - Santa Barbara CA, US
Jason Sagert - Santa Barbara CA, US
Assignee:
The Regents of the University of California - Oakland CA
CytomX Therapeutics, Inc. - South San Francisco CA
CytomX Therapeutics, Inc. - South San Francisco CA
International Classification:
C12P 21/08, C12N 15/74, C07H 21/04, C07K 16/22, C07K 16/46, C07K 14/00
US Classification:
435 691, 435 711, 435328, 435335, 536 234, 536 2353, 4241341, 4241921, 4241931
Abstract:
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Activatable Binding Polypeptides And Methods Of Identification And Use Thereof
US Patent:
8529898, Sep 10, 2013
Filed:
Mar 6, 2012
Appl. No.:
13/413447
Inventors:
Patrick Sean Daugherty - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Jason Sagert - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Jason Sagert - Santa Barbara CA, US
Assignee:
The Regents of the University of California - Oakland CA
CytomX Therapeutics, Inc. - South San Francisco CA
CytomX Therapeutics, Inc. - South San Francisco CA
International Classification:
C07K 16/22, C07K 16/46, C07K 14/00, A61K 39/00, A61K 49/16
US Classification:
4241341, 4241451, 4241921, 5303873, 53038824
Abstract:
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.
Activatable Binding Polypeptides And Methods Of Identification And Use Thereof
US Patent:
8518404, Aug 27, 2013
Filed:
Mar 2, 2012
Appl. No.:
13/411409
Inventors:
Patrick Daugherty - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Jason Sagert - Santa Barbara CA, US
Nancy Stagliano - Santa Barbara CA, US
Jerry Thomas - Goleta CA, US
Kathryn Kamath - Santa Barbara CA, US
James W. West - Santa Barbara CA, US
Sanjay Khare - Newbury Park CA, US
Jason Sagert - Santa Barbara CA, US
Assignee:
The Regents of the University of California - Oakland CA
CytomX Therapeutics, Inc. - South San Francisco CA
CytomX Therapeutics, Inc. - South San Francisco CA
International Classification:
A61K 39/00, A61K 39/395, C07K 16/28, C07K 16/46
US Classification:
4241341, 4241921, 4241431, 5303873, 53038823, 5303913
Abstract:
Activatable binding polypeptides (ABPs), which contain a target binding moiety (TBM), a masking moiety (MM), and a cleavable moiety (CM) are provided. Activatable antibody compositions, which contain a TBM containing an antigen binding domain (ABD), a MM and a CM are provided. Furthermore, ABPs which contain a first TBM, a second TBM and a CM are provided. The ABPs exhibit an “activatable” conformation such that at least one of the TBMs is less accessible to target when uncleaved than after cleavage of the CM in the presence of a cleaving agent capable of cleaving the CM. Further provided are libraries of candidate ABPs, methods of screening to identify such ABPs, and methods of use. Further provided are ABPs having TBMs that bind VEGF, CTLA-4, or VCAM, ABPs having a first TBM that binds VEGF and a second TBM that binds FGF, as well as compositions and methods of use.