Inventors:
Jerome Ritz - Lincoln MA, US
Xiao-Feng Yang - Houston TX, US
Catherine Wu - Cambridge MA, US
International Classification:
G01N033/574, A61K039/395
Abstract:
The invention provides human chronic myelocytic leukemia-like proteins (CML protein) and isolated nucleic acid molecules encoding the same. Also provided are antibodies that immunospecifically-bind to CML polypeptides or polynucleotides, or derivatives, variants, mutants, or fragments thereof. The invention additionally provides methods in which CML polypeptides, polynucleotides, and antibodies are used in the detection, prevention, and treatment of a broad range of pathological states, and methods of treating malignancy-related disorders by modulating activity or expression of CML proteins.