Inventors:
Peter M. Abadir - Woodstock MD, US
Jeremy D. Walston - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
G01N 33/566, A61K 31/4184, A61K 31/4178, A61K 31/41
US Classification:
514381, 514394, 514397, 435 29, 435375
Abstract:
Provided herein is a novel mitochondrial Angiotensin II type 1 and type 2 ATR and ATR receptor which plays a role in protection of mitochondria against oxidative damage. Evidence from animal studies indicates a role for this receptor in preservation of mitochondria and up-regulation of survival genes, anti-inflammatory action, and improvement of wound healing in the skin and soft tissues. Pharmaceutical compositions for treatment directed to preserving mitochondrial function, anti-inflammation, wound healing and decreasing the signs of aging, as well as medicaments and their use are also provided.