Inventors:
Jere P. Segrest - Birmingham AL
Gattadahalli M. Anantharamaiah - Birmingham AL
Assignee:
Research Corporation - New York NY
International Classification:
A61K 3743, C07K 708, C07K 710
Abstract:
The present invention relates to peptides of the formula
A. sub. 1 -B. sub. 1 -B. sub. 2 -C. sub. 1 -D-B. sub. 3 -B. sub. 4 -A. sub. 2 -C. sub. 2 -B. sub. 5 -B. sub. 6 -A. sub. 3 -C. sub. 3 -B. sub. 7 -C. sub. 4 -A. sub. 4 -B. sub. 8 -B. sub. 9
wherein:
A. sub. 1, A. sub. 2, A. sub. 3 and A. sub. 4 are independently aspartic acid or glutamic acid, or homologues or analogues thereof;
B. sub. 1, B. sub. 2, B. sub. 3, B. sub. 4, B. sub. 5, B. sub. 6, B. sub. 7, B. sub. 8 and B. sub. 9 are independently tryptophan, phenylalanine, leucine, alanine, tyrosine, isoleucine, valine or. alpha. -naphtylalanine, or homologues or analogues thereof; C. sub. 1, C. sub. 2, C. sub. 3, and C. sub. 4 are independently lysine or arginine, or homologues or analogues thereof, and D is serine, threonine, alanine, glycine, or histidine; provided that, when A. sub. 1 and A. sub. 2 are aspartic acid, A. sub. 3 and A. sub.