Inventors:
Wolfgang M. Sigmund - Gainesville FL, US
Yi-Yang Tsai - Brandon FL, US
Ioannis Constantinidis - Gainesville FL, US
Jenny Dorley - Gainesville FL, US
Carol Ann Sweeney - Micanopy FL, US
Nicholas Edward Simpson - Alachua FL, US
Mark A. Atkinson - Gainesville FL, US
Assignee:
UNIVERSITY OF FLORIDA RESEARCH FOUNDATION, INC. - GAINESVILLE FL
International Classification:
A61K 9/14, A61K 35/12, A61K 33/24
US Classification:
424489, 424 937, 424617, 435375, 977773, 977904
Abstract:
The present invention concerns metal oxide semiconductor nanoparticles with free radical scavenging activity, compositions comprising such nanoparticles, methods for their use, and methods for their production. In one aspect, the invention concerns a method for enhancing the survival or viability of transplanted cells, comprising administering an effective amount of metal oxide semiconductor nanoparticles to a target anatomical site of a subject before, during, or after administration of transplant cells to the subject. Preferably, the metal oxide nanoparticle is a cerium oxide (ceria) nanoparticle.