JENNIFER LEE VAN LUE, LCSWA
Social Work at Patton Ave, Asheville, NC
License number
North Carolina P007642
Category
Social Work
Type
Clinical
Address
Address
2
1316 Patton Ave, Asheville, NC 28806
PO Box 759194, Baltimore, MD 21275
PO Box 759194, Baltimore, MD 21275
Phone
(828) 225-3100
(828) 225-3604 (Fax)
(540) 710-6085
(540) 710-6447 (Fax)
(828) 225-3604 (Fax)
(540) 710-6085
(540) 710-6447 (Fax)
Professional information
Methods And Compositions For Modulating Adenosine Triphosphate (Atp) In Cells And Preventing Cell Injury Or Death Via Post-Translational Modifications To Atp Synthase
US Patent:
2008018, Jul 31, 2008
Filed:
Feb 6, 2008
Appl. No.:
12/027072
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
David Kent Arrell - Rochester MN, US
David Kent Arrell - Rochester MN, US
International Classification:
C12Q 1/00, C12Q 1/02
US Classification:
435 4, 435 29
Abstract:
Compositions and methods for modulating adenosine triphosphate (ATP) in cells via altering post-translational modifications of ATP synthase subunits or precursors thereof such as the ATP synthase β chain and its precursor are provided. These compositions and methods are useful in preconditioning organs and preventing cell injury or cell death via regulating ATP synthesis or hydrolysis in cells of the organs.
Methods And Compositions For Modulating Proteins Modified In Preconditioning Against Ischemia/Hypoxia
US Patent:
7195890, Mar 27, 2007
Filed:
Apr 14, 2004
Appl. No.:
10/824027
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
Steven T. Elliott - Cockeysville MD, US
David Kent Arrell - Rochester MN, US
Steven T. Elliott - Cockeysville MD, US
David Kent Arrell - Rochester MN, US
Assignee:
Queen's University at Kingston - Kingston
International Classification:
C12Q 1/26
US Classification:
435 25, 435 721
Abstract:
Proteins modified by pharmacological preconditioning are provided. Compositions, methods and events for modulating these proteins and priming cells for preconditioning and inducing preconditioning in a cell, tissue or organ as well as methods for identifying new compositions and methods for such priming and induction are also provided. In addition, methods for diagnosing and monitoring preconditioning or ischemic, hypoxic, ischemic/reperfusion and hypoxic/reperfusion conditions or the ability of a cell, tissue or organ to survive injury by measuring modulation of one or more of these preconditioning proteins are provided.
Method, Kit Or Diagnostic For The Detection Of Reagents Which Induce Altered Contractility
US Patent:
2012023, Sep 13, 2012
Filed:
Nov 15, 2010
Appl. No.:
13/509397
Inventors:
Christopher I. Murray - Baltimore MD, US
Jennifer E. Van Eyk - Baltimore MD, US
Nazareno Paolocci - Baltimore MD, US
Wei Dong Gao - Woodstock MD, US
Darren Brian Foster - Baltimore MD, US
Jennifer E. Van Eyk - Baltimore MD, US
Nazareno Paolocci - Baltimore MD, US
Wei Dong Gao - Woodstock MD, US
Darren Brian Foster - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
C12Q 1/02, C07K 14/47, C12Q 1/37, G01N 33/53, G01N 27/62
US Classification:
435 792, 435 29, 435 71, 435 23, 530350
Abstract:
A method of screening for compounds that enhance or depress contractile function, based on measuring the formation of heterodimers of contractile fibers (e.g. Tm and actin, myosin heavy and myosin light chains), for example through disulfide bond formation. Diagnostic and prognostic methods and kits are also provided.
Methods And Kits For Separation And Detection Of Proteins In Biological Samples
US Patent:
7709193, May 4, 2010
Filed:
May 26, 2005
Appl. No.:
11/138184
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
Jeremy A. C. Simpson - Kingston, CA
Jeremy A. C. Simpson - Kingston, CA
Assignee:
Queen's University at Kingston - Kingston, Ontario
International Classification:
C12Q 1/68
US Classification:
435 6
Abstract:
Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells and in the early clinical diagnosis of myocardial damage by detection of myofilament proteins in serum of a subject.
Peptide Antibody Depletion And Its Application To Mass Spectrometry Sample Preparation
US Patent:
2012027, Nov 1, 2012
Filed:
Jun 28, 2012
Appl. No.:
13/536047
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
David Raymond Graham - Arbutus MD, US
Rebekah Lynn Gundry - Baltimore MD, US
David Raymond Graham - Arbutus MD, US
Rebekah Lynn Gundry - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
G01N 1/28, G01N 27/62, C07K 16/00, C12Q 1/37
US Classification:
435 23, 436175, 5303871, 5303881, 422527
Abstract:
The present invention relates, e.g., to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other methods; analytic (diagnostic) methods using antibodies against highly ionizable peptides from a protein target of interest; and compositions, kits and devices comprising antibodies of the invention.
Novel Phosphorylation Of Cardiac Troponin I As A Monitor For Cardiac Injury
US Patent:
2013010, Apr 25, 2013
Filed:
Feb 17, 2011
Appl. No.:
13/579797
Inventors:
Pingbo Zhang - Ellicott City MD, US
Jennifer E. Van Eyk - Baltimore MD, US
Anne M. Murphy - Towson MD, US
Ger Stienen - Abcoude, NL
Jolanda van der Velden - Amsterdam, NL
Viola Kooij - Alphen, NL
Jennifer E. Van Eyk - Baltimore MD, US
Anne M. Murphy - Towson MD, US
Ger Stienen - Abcoude, NL
Jolanda van der Velden - Amsterdam, NL
Viola Kooij - Alphen, NL
Assignee:
VU-VUMC IP MANAGEMENT BV - Amsterdam NL
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
G01N 33/68
US Classification:
4241721, 435 71, 5303898, 5303882, 5303913, 977774
Abstract:
This invention relates to novel phosphorylation sites in cardiac Troponin I that are associated with the onset of heart failure. The phosphorylation sites, i.e., serine 5, tyrosine 26, threonine 51, serine 166, threonine 181 and/or serine 199, can be used as biomarkers for (i) identifying subjects at risk for the development of heart failure, (ii) treating subjects having a higher than normal level of the biomarker, and (iii) monitoring therapy of a subject at risk for the development of heart failure. Also described are antibodies, reagents, and kits for carrying out a method of the present invention.
Peptide Antibody Depletion And Its Application To Mass Spectrometry Sample Preparation
US Patent:
8232066, Jul 31, 2012
Filed:
Jul 3, 2007
Appl. No.:
12/307510
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
David Raymond Graham - Baltimore MD, US
Rebekah Lynn Gundry - Baltimore MD, US
David Raymond Graham - Baltimore MD, US
Rebekah Lynn Gundry - Baltimore MD, US
Assignee:
The Johns Hopkins University - Baltimore MD
International Classification:
G01N 31/00, G01N 33/53
US Classification:
435 721, 435 71, 436501, 436518, 424 91, 424520, 422 50, 530300, 530350
Abstract:
The present invention relates, e. g. , to a method for pre-processing a sample for mass spectral analysis, comprising cleaving proteins in the sample to peptides and immunodepleting highly abundant and/or well-ionizing and/or proteotypic peptides from the sample. Also described are methods for identifying well-ionizing peptides for use in this and other methods; analytic (diagnostic) methods using antibodies against highly ionizable peptides from a protein target of interest; and compositions kits and devices comprising antibodies of the invention.
Methods And Kits For Separation And Detection Of Proteins In Biological Samples
US Patent:
8481274, Jul 9, 2013
Filed:
Apr 30, 2010
Appl. No.:
12/771351
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
Jeremy A. C. Simpson - Kingston, CA
Jeremy A. C. Simpson - Kingston, CA
Assignee:
Queen's University at Kingston - Ontario
International Classification:
G01N 33/53
US Classification:
435 71
Abstract:
Methods and kits are provided for separating a mixture of proteins in a biological sample. Methods for detecting and profiling proteins in biological samples by the separation method and kits are also provided. These methods are particularly useful in assessing damage to cells such as cardiac and skeletal muscle cells and in the early clinical diagnosis of myocardial damage by detection of myofilament proteins in serum of a subject.
Albumin-Bound Protein/Peptide Complex As A Biomarker For Disease
US Patent:
2011014, Jun 16, 2011
Filed:
Jun 14, 2007
Appl. No.:
12/304895
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
Rebekah Lynn Gundry - Baltimore MD, US
Robert J. Cotter - Baltimore MD, US
Rebekah Lynn Gundry - Baltimore MD, US
Robert J. Cotter - Baltimore MD, US
Assignee:
Johns Hopkins University - Baltimore MD
International Classification:
G01N 33/68, G01N 33/72, G01N 33/92, B01D 59/44, G01N 30/02
US Classification:
436501, 436 66, 436 88, 436 71, 250282, 73 6152
Abstract:
Methods and kits for diagnosis and prognosis using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).
Albumin-Bound Protein/Peptide Complex As A Biomarker For Disease
US Patent:
2013023, Sep 12, 2013
Filed:
Nov 14, 2011
Appl. No.:
13/885144
Inventors:
Jennifer E. Van Eyk - Baltimore MD, US
Ronald Joseph Holewinski - Baltimore MD, US
Ronald Joseph Holewinski - Baltimore MD, US
Assignee:
THE JOHNS HOPKINS UNIVERSITY - Baltimore MD
International Classification:
G01N 33/68
US Classification:
435 792, 435 23, 436501
Abstract:
Methods and kits provide for diagnosis and prognosis of ischemia by using biomarkers comprising albumin-bound protein/peptide complex (ABPPC).