Inventors:
Michele Youd - Lexington MA, US
Jennifer Tedstone - Hopkinton MA, US
Tracey Lodie - Northbridge MA, US
Karen B. Carter - Fiskdale MA, US
Timothy D. Connors - Shrewsbury MA, US
Jason Robert Pinckney - Marlborough MA, US
Elizabeth Masterjohn - Hudson MA, US
Ruiyin Chu - Belle Mead NJ, US
Assignee:
Genzyme Corporation - Cambridge MA
International Classification:
C07K 16/28, A61K 45/06, A61K 39/395
US Classification:
4241721, 5303891, 5303873, 5303879, 536 2353, 514 44 R, 5303911, 5303917, 4353201, 43525233, 435 696, 435 724, 435334
Abstract:
The present disclosure provides anti-CXCR3 antibodies and methods of using the antibodies to diagnose and/or treat CXCR3-associated disorders such as diabetes mellitus type I (T1D), particularly new-onset T1D. In certain embodiments, disclosed herein are CXCR3 neutralizing antibodies.