Inventors:
Lih-Ling Lin - Concord MA, US
Jennifer Chen - Chestnut Hill MA, US
Andrea R. Schievella - Winchester MA, US
James Graham - Somerville MA, US
International Classification:
A61K 39/395, C12N 15/11, C12N 5/06, C12P 21/04, C07K 14/00, C12Q 1/68, A61K 38/16, C07K 16/18, G01N 33/566
US Classification:
4241391, 536 231, 435325, 435 691, 530350, 514 12, 5303879, 436501, 435 6
Abstract:
Novel TNF receptor death domain (“TNF-R1-DD”) ligand proteins are disclosed. Polynucleotides encoding the TNF-R1-DD ligand protein are also disclosed, along with vectors, host cells, and methods of making the TNF-R1-DD ligand protein. Pharmaceutical compositions containing the TNF-R1-DD ligand protein, methods of treating inflammatory conditions, and methods of inhibiting TNF-R death domain binding are also disclosed. Methods of identifying inhibitors of TNF-R death domain binding and inhibitors identified by such methods are also disclosed.