Inventors:
Rodolfo Cadilla - Durham NC, US
Brad Richard Henke - Durham NC, US
Guangcheng Kevin Liu - San Diego CA, US
Jennifer Susan Smith - Durham NC, US
Assignee:
SmithKline Beecham Corporation - Philadelphia PA
International Classification:
A61K 31/505, A61K 31/42, A61K 31/445, A61K 31/425, C07D 239/02
US Classification:
514275, 514324, 514374, 514331, 514365, 544323, 548187, 548235
Abstract:
Compounds of formula (1) or a pharmaceutically acceptable salt, solvate, acid isostere, or hydrolyzable ester thereof, are disclosed. Methods of making and using the compounds are also disclosed. In particular methods for treating diseases or conditions associated with one or more of human PPAR alpha, gamma, or delta (“hPPARs”) comprising administration of a therapeutically effective amount of a compound of formula (1), are disclosed.