Inventors:
Heather Ann Beam - North Brunswick NJ, US
Thomas J. Bradbury - Yardley PA, US
Kathleen D. Chesmel - Cream Ridge NJ, US
Christopher M. Gaylo - Princeton Junction NJ, US
Alfred Anthony Litwak - Manasquan NJ, US
Qing Liu - Lawrenceville NJ, US
Peter Albert Materna - Metuchen NJ, US
Donald Monkhouse - Radnor PA, US
Jennifer Patterson - Seattle WA, US
Timothy J. Pryor - Yardley PA, US
Sunil Saini - Plainsboro NJ, US
Henry Leon Surprenant - Phoenixville PA, US
Thomas George West - Lawrenceville NJ, US
Jaedeok Yoo - West Orange NJ, US
International Classification:
A61F 2/28
Abstract:
An engineered regenerative biostructure (erb) for implantation into a human body as a bone substitute, which includes an internal microstructure, mesostructure and/or macrostructure to provide improved bone in-growth, and methods for making the erb. Under one aspect of the invention, the biostructure has resorbable and nonresorbable regions. Under another aspect of the invention, the biostructure is constructed of hydroxyapatite, tricalcium phosphate and/or demineralized bone. Under yet another aspect of the invention, the porous biostructure is partially or fully infused with a resorbable, nonresorbable or dissolvable material.