Inventors:
Jeffrey W. Corbett - Niantic CT, US
Angel Guzman-Perez - Mystic CT, US
Jeffrey A. Pfefferkorn - Mystic CT, US
Meihua Tu - Mystic CT, US
International Classification:
A61K 31/497, C07D 403/14, A61K 31/506, A61K 31/4439, C07D 403/12, A61K 31/416, C07D 401/12, C07D 413/14, A61K 31/5377, C07D 417/12, A61K 31/433, A61K 31/4192, C07D 409/14, A61P 3/04, A61P 3/10, C07D 401/14
US Classification:
51421018, 544405, 51425505, 544295, 5462757, 514338, 5483611, 514407, 544120, 5142345, 548128, 514361, 548255
Abstract:
The present invention provides a compound of Formula (I) or a pharmaceutically acceptable salt thereof wherein R, R, R, X, Y and Z are as defined herein. The compounds of Formula (I) have been found to act as glucokinase activators. Consequently, the compounds of Formula (I) and the pharmaceutical compositions thereof are useful for the treatment of diseases, disorders, or conditions mediated by glucokinase.