JEFFREY W. CLARK
Physician in Providence, RI

License number

Rhode Island MD07387

Issued Date

Jul 9, 1988

Expiration Date

Jan 1, 1996

Professional information

English Teacher At Bishop Hendricken Hs

Position:

English Teacher at Bishop Hendricken HS

Location:

Providence, Rhode Island Area

Industry:

Education Management

Work:

Bishop Hendricken HS - English Teacher

Education:

University of Vermont 1991 - 1995

Treatment Of Tumorigenic Pathophysiological Conditions With Fgf-Cytoxic Conjugates

US Patent:

5478804, Dec 26, 1995

Filed:

May 26, 1994

Appl. No.:

8/250097

Inventors:

Paul Calabresi - Barrington RI
Julie G. Beitz - Rumford RI
Jeffrey W. Clark - Providence RI
A. Raymond Frackelton - Rumford RI
Douglas A. Lappi - Del Mar CA
Andrew J. Baird - San Diego CA

Assignee:

The Salk Institute for Biological Studies - San Diego CA
Roger Williams General Hospital - Providence RI

International Classification:

A61K 3818, A61K 3843

US Classification:

514 2

Abstract:

Conjugates comprising bFGF or other FGF polypeptides and a cytotoxic agent are prepared. The cytotoxic agent can be a ribosome-inactivating protein (RIP), such as saporin, which is attached to bFGF through a chemical bond, or the composition can be prepared as a recombinant DNA chimera. The conjugates are used to specifically target cells, in vivo and in vitro, which express FGF receptors. The cytotoxicity of the conjugates is proportional to the number of receptors expressed by a cell type. The conjugate is useful to effectively treat mammals, and in particular human patients, afflicted with tumorigenic conditions, such as human melanomas, human ovarian carcinomas, teratocarcinomas and neuroblastomas, and other FGF-mediated tumors caused by a proliferation of cells which express FGF receptors.